- March 15, 2022
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Brand Name :
Alocillin, Alocin, Azlocillin, Azlin
Synonyms :
Azlocillin sodium
Class :
Antibiotics and Penicillins
Dosage Forms & strengths:
1.05g of azlocillin sodium is equivalent to about 1g of azlocillin.
Injectable solution:
100mg/30ml
pseudomonas aeruginosa infections
10% IV solution:
2
g
every 8 hrs
For life-threatening infection: 5g every 8hr. Higher doses should be infused over 20 to 30 minutes.
The dose can be modified as per symptoms and intensity of infection.
2
g
Intravenous (IV)
every 8 hrs
, For severe cases 5g every 8 to 10hr
2
g
Intravenous (IV)
every 8 hrs
, increase the dose depending on the severity of the infection
For creatinine clearance <30ml/min:
2
g
Intravenous (IV)
every 8 hrs
increased at 12hr intervals
Dose reduction may be required in case of hepatic impairment
Dosage Forms & strengths:
1.05g of azlocillin sodium is equivalent to about 1g of azlocillin.
Injectable solution:
100mg/30ml
pseudomonas aeruginosa infections
For children up to 14yr:
75
mg/kg
Intravenous (IV)
3 times a day
(do not exceed more than 2g/dose)
For 7 days to 1yr: 50mg/kg three times a day
For neonates <7 days: 50mg/kg twice a day
For children up to 14yr:
75
mg/kg
Intravenous (IV)
3 times a day
(do not exceed more than 2g/dose)
For 7 days to 1yr: 50mg/kg three times a day
For neonates <7 days: 50mg/kg twice a day
Infants 7 days to 1yr:
50
mg/kg
Intravenous (IV)
3 times a day
For neonates <7 days: 50mg/kg twice a day
For creatinine clearance <30ml/min (children up to 14yr): 2g IV every 8 hours increased at 12hr intervals
Dose reduction may be required in case of hepatic impairment
The risk of seizure can be increased when combined with azlocillin.
The risk of seizure may be increased.
Decrease renal clearance.
Increase systemic circulation of mycophenolate metabolites by hepatic reuptake.
Therapeutic efficacy of azlocillin may decrease.
The therapeutic effects of the BCG vaccine can be decreased when interacting with azlocillin.
Therapeutic efficacy of azlocillin may decrease.
Therapeutic efficacy of azlocillin may decrease.
Therapeutic efficacy of azlocillin may decrease.
Increased anticoagulant activities of acenocoumarol.
Decrease the excretion rate of azlocillin which could result in a higher serum level of the drug.
Therapeutic activity decreased of acetazolamide.
Decreased therapeutic activity of brexanolone.
Decreased therapeutic activity of brivaracetam.
Decreased therapeutic efficacy of butalbital.
Decreased therapeutic efficacy of carbamazepine.
Decreased therapeutic efficacy of cenobamate.
Decreased therapeutic efficacy of diazepam.
probenecid may increase the serum concentration of penicillins
acemetacin: they may enhance the serum concentration of penicillins
Therapeutic activity of atracurium increased when combined with azlocillin.
Decreased serum concentration of amikacin.
Serum concentration increased of cinoxacin.
Patients with a history of sensitivity to multiple allergens or hypersensitivity to beta-lactams may develop severe anaphylactoid reactions with azlocillin therapy.
Patient information leaflet
Generic Name: azlocillin
Why do we use azlocillin?
azlocillin is a type of antibiotic that is used to treat bacterial infections. It belongs to the group of antibiotics called penicillins, which work by inhibiting the growth of bacteria and preventing them from reproducing.
azlocillin is particularly effective against gram-negative bacteria, which are a type of bacteria that have a thin outer membrane that makes them resistant to many antibiotics. Gram-negative bacteria can cause a wide range of infections, including urinary tract infections, respiratory infections, skin infections, and sepsis.
azlocillin is often used to treat infections caused by gram-negative bacteria, especially Pseudomonas aeruginosa, which is a common cause of infections in hospitals and can be difficult to treat with other antibiotics. It is also used to treat infections in patients who are immunocompromised or have other medical conditions that make them more susceptible to bacterial infections.
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