amlodipine/telmisartan

medtigo

amlodipine/telmisartan

Brand Name :

Twynsta

Synonyms :

amlodipine/telmisartan

Class :

Angiotensin receptor II inhibitors, Calcium channel blockers

Action and Spectrum

Mechanism of action

amlodipine is a calcium channel blocker that works by blocking the entry of calcium into the cells of the blood vessels, thereby relaxing the blood vessels and allowing for better blood flow. This results in a decrease in blood pressure. amlodipine has a broad spectrum of activity and can effectively lower blood pressure in patients with mild to moderate hypertension
telmisartan, on the other hand, is an angiotensin receptor blocker (ARB) that works by blocking the action of angiotensin II, a hormone that causes blood vessels to narrow.

By blocking the action of angiotensin II, telmisartan helps to dilate blood vessels and lower blood pressure. It also effectively reduces the risk of cardiovascular events such as heart attack and stroke. When used together, amlodipine and telmisartan provide additive blood pressure-lowering effects, making them an effective combination therapy for the treatment of hypertension. The combination of these two medications has been shown to effectively lower blood pressure in many patients, including those with severe hypertension and those who have not achieved adequate blood pressure control with monotherapy

Spectrum

The combination of amlodipine and telmisartan has a broad spectrum of activity and is used to treat hypertension (high blood pressure) in many patients. The combination therapy is particularly effective in patients who have not achieved adequate blood pressure control with monotherapy or who have severe hypertension

Dosing & Uses

Drug Interaction

Adverse Reaction

Frequency defined:

10%

Peripheral edema (1-11%)

1-10%

Orthostatic hypotension (6%)

Back pain (2%)

Dizziness (3%)

Syncope (2%)

Post-marketing reports

asthenia, nausea, hypoglycemia, upper respiratory tract infection, jaundice, headache, coughing, fatigue, angioedema, gynecomastia, extrapyramidal syndrome

Black Box Warning

Contraindication / Caution

Contraindications

It is contraindicated in hypersensitivity and Patients with diabetes mellitus should not receive aliskiren in combination with them
Caution

Hypotension: It can lower blood pressure, leading to dizziness, light-headedness, and fainting. Patients should be cautious when standing up after sitting or lying down for an extended period.
Liver disease: It is metabolized in the liver, so it should be used cautiously in patients with liver disease.
Heart failure: It may worsen heart failure in some patients. It should be used cautiously in patients with heart failure or left ventricular dysfunction.
Pregnancy: It should not be used during pregnancy, as it can cause harm to the developing foetus. Women of childbearing age should use effective contraception while taking telmisartan

Pregnancy / Lactation

Pregnancy consideration:

It should not be used during pregnancy, as it can cause harm to the developing foetus

Lactation: Excretion of the drug in human breast milk is unknown

Pregnancy category:

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.

Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology

amlodipine is a dihydropyridine calcium channel blocker that blocks the influx of calcium ions into vascular smooth muscle cells, resulting in the relaxation of the blood vessels and a reduction in blood pressure. Amlodipine has a long duration of action and is typically given once daily telmisartan is an angiotensin II receptor blocker (ARB) that works by blocking the action of the hormone angiotensin II on its receptors in the blood vessels and other tissues. This results in the relaxation of the blood vessels and a reduction in blood pressure. Telmisartan has a long duration of action and is typically given once daily. In addition to its antihypertensive effects, telmisartan has been shown to have other beneficial effects, such as reducing inflammation and improving insulin sensitivity

Pharmacodynamics

amlodipine and telmisartan reduce blood pressure but do so through different mechanisms.amlodipine blocks calcium channels, while telmisartan works by blocking angiotensin II receptors

Pharmacokinetics

Absorption

telmisartan has a half-life of 24 hours, an onset of action of 1-2 hours, and a bioavailability of 42-58%, which is dose-dependent. amlodipine has a half-life of 30-50 hours, a bioavailability of 64-90%, and a Vd of 21 L/kg. Its peak plasma time is 6-12 hours

Distribution

Its volume of distribution (Vd) is 500 L, and its peak plasma time is 0.5-1 hour

Metabolism

telmisartan is highly protein-bound (>99.5%), and it is primarily metabolized in the liver to an inactive metabolite that is not metabolized by CYP enzymes. amlodipine is highly protein-bound (93-98%), and it is primarily metabolized in the liver by the P450 CYP3A4 enzyme

Elimination/excretion

telmisartan has a clearance of 800 mL/min, and it is mainly excreted in the faeces (97%). amlodipine has a clearance of 25 L/hr, and it is mainly excreted in the urine (70%)

Adminstartion

Administration

amlodipine is available in tablet form in strengths ranging from 2.5 to 10 mg. The recommended starting dose of amlodipine is usually 5 mg once daily, and the maximum dose is 10 mg once daily. amlodipine can be taken with or without food, but it should be taken simultaneously every day telmisartan is available in tablet form in strengths ranging from 20 to 80 mg. The recommended starting dose of telmisartan is usually 20 mg once daily, and the maximum dose is 80 mg once daily.

Telmisartan can be taken with or without food, but it should be taken simultaneously every day It is essential to take these medications exactly as the healthcare provider prescribes, even if the patient is feeling well. Abruptly stopping these medications may result in a rebound increase in blood pressure, which may lead to serious health consequences. If a dose is missed, it should be taken as soon as possible unless it is almost time for the next dose, in which case the missed dose should be skipped, and the regular dosing schedule resumed

Patient Information Leaflet

Patient information leaflet

Generic Name: amlodipine/telmisartan

Pronounced: [ am-LOE-de-peen-and-TEL-me-SAR-tan]

Why do we use amlodipine/telmisartan?

amlodipine is a calcium channel blocker used to treat hypertension and angina (chest pain). It is often prescribed in combination with other medications for the treatment of hypertension, such as angiotensin-converting enzyme (ACE) inhibitors, diuretics, and beta-blockers.

telmisartan is an angiotensin II receptor blocker (ARB) used to treat hypertension. It is often used with other medications, such as diuretics and calcium channel blockers, to lower blood pressure. In addition to its blood pressure-lowering effects, telmisartan has been shown to have anti-inflammatory and antioxidant properties, and it may have additional benefits for patients with cardiovascular disease.

amlodipine/telmisartan

No data available for drug.

DRUG INTERACTION

amlodipine/telmisartan

&

amlodipine/telmisartan +

Contraindicated

Serious Use Alternative

Monitor Closely

Minor

amlodipine/telmisartan

No data available for drug.

DRUG INTERACTION

amlodipine/telmisartan

&

amlodipine/telmisartan +

Contraindicated

Serious Use Alternative

Monitor Closely

Minor

medtigo

amlodipine/telmisartan

Brand Name :

Synonyms :

Class :

Action and Spectrum

Dosing & Uses

Drug Interaction

Adverse Reaction

Black Box Warning

Contraindication / Caution

Pregnancy / Lactation

Pharmacology

Adminstartion

Patient Information Leaflet

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