eszopiclone

medtigo

eszopiclone

Brand Name :

lunesta

Synonyms :

eszopiclone

Class :

Sedative

Action and Spectrum

Mechanism of action

It is a nonbenzodiazepine hypnotic drug that acts as an agonist at the GABA-A receptor. Its mechanism of action enhances the effect of GABA, a neurotransmitter in the brain that promotes sleep, leading to a decrease in sleep latency and an improvement in sleep quality.

Spectrum

Its spectrum of activity is for the treatment of insomnia, particularly for difficulty falling and staying asleep

Dosing & Uses

Drug Interaction

Adverse Reaction

Frequency defined:

>10%

Unpleasant taste

headache

1-10%

Accidental injury

Dizziness

Dyspepsia

Neuralgia

Pruritis

Somnolence

UTI

Abnormal dreams

Diarrhea

Dry mouth

Nervousness

Pain

Rash

Unpleasant tase

<1%

Alopecia

Asthma

Cystitis

Fever

Hypertension

Hypercholesterolemia

Agitation

Angioedema

Anorexia

Dysphagia

Epistaxis

Hostility

Hypokalemia

Post-marketing reports

Complex sleep behaviors

dysosmia

Black Box Warning

Black box warning

It can cause complex sleep behaviors, including sleepwalking, sleep-driving, and performing other activities while not fully awake. These behaviors can result in severe injury or even death. If a patient experiences such behavior, it is essential to discontinue drug use immediately.

Contraindication / Caution

Contraindications

Hypersensitivity reactions

Caution

May cause complex sleep behaviors
May impair next-day alertness and performance
It may cause dependence and withdrawal symptoms
Should not be used with alcohol or other CNS depressants
It may interact with other medications
It may not be safe for use in pregnancy or breastfeeding
Not recommended for long-term use

Pregnancy / Lactation

Pregnancy consideration: Insufficient data available

Lactation: Excretion of the drug in human breast milk is unknown

Pregnancy category:

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.

Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology

The exact mechanism by which eszopiclone interacts with GABA receptor complexes is unknown. However, it is thought to act at binding domains allosterically coupled to benzodiazepine receptors, leading to an enhancement of the effect of GABA, a neurotransmitter that promotes sleep. This results in a decrease in sleep latency and an improvement in the quality of sleep.

Pharmacodynamics

It is a nonbenzodiazepine hypnotic drug that acts as an agonist at the GABA-A receptor. Its pharmacodynamics involves enhancing the effect of GABA, a neurotransmitter in the brain that promotes sleep, leading to a decrease in sleep latency and an improvement in sleep quality. This is achieved by binding to specific sites on the GABA-A receptor, which leads to an increase in the affinity of GABA for the receptor and an enhancement of its inhibitory effect on the nervous system, resulting in sedation and improved sleep. The onset of action is typically within 30 minutes, and the duration of action is generally 6-8 hours.

Pharmacokinetics

Absorption: It is well absorbed after oral administration, with peak plasma concentrations reached in approximately 1-2 hours.

Distribution: It is widely distributed throughout the body. Its volume of distribution is approximately 0.9 L/kg

Metabolism: It is primarily metabolized by the liver, and its metabolites are primarily excreted in the urine

Elimination/Excretion: The elimination half-life of eszopiclone is approximately 6 hours. It is eliminated primarily through renal excretion, with less than 10% of the dose excreted unchanged in the urine.

Adminstartion

Administration

It is a medication that is taken orally, usually at bedtime. The recommended dose is 1 to 2 mg. It is essential to take it precisely as a healthcare provider directed and not exceed the recommended dose.

Patient Information Leaflet

Patient information leaflet

Generic Name: eszopiclone

Pronounced: [ e-ZOP-i-klone ]

Why do we use eszopiclone?

It treats insomnia (difficulty falling asleep or staying asleep). It works by affecting certain chemicals in the brain that may become unbalanced and cause sleep problems.

eszopiclone

No data available for drug.

DRUG INTERACTION

eszopiclone

&

eszopiclone +

Contraindicated

Serious Use Alternative

Monitor Closely

Minor

eszopiclone

No data available for drug.

DRUG INTERACTION

eszopiclone

&

eszopiclone +

Contraindicated

Serious Use Alternative

Monitor Closely

Minor

medtigo

eszopiclone

Brand Name :

Synonyms :

Class :

Action and Spectrum

Dosing & Uses

Drug Interaction

Adverse Reaction

Black Box Warning

Contraindication / Caution

Pregnancy / Lactation

Pharmacology

Adminstartion

Patient Information Leaflet

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