- March 15, 2022
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Brand Name :
Amoxil, Trimox, Moxatag, Sumox, Moxillin, Larotid, Trumox
Synonyms :
Class :
Class: Antimicrobials and Antiviral drugs; Sub class: Penicillins
Dosage forms and strengths:
Oral solution
125mg per 5ml
200mg per 5ml
250mg per 5ml
400mg per 5ml
Capsule
250mg
500mg
Tablet
500mg
875mg
Tablet, chewable
125mg
250mg
Age: 18-64 years
group A Streptococcal (GAS) infections
500
mg
2 times a day or 1 g daily
10
days
ER: 775 mg daily for 10 days
lower Respiratory Tract Infections
Mild/moderate/severe:
875
mg
every 12 hrs or 500mg every 8hrs
Mild/moderate/severe:
3
g
as a single dose
genitourinary Tract Infections
Mild/Moderate:
500
mg
every 12 hrs or 250 mg every 8hrs
Severe: 875 mg every 12hrs or 500mg every 8hrs
Mild/Moderate:
500
mg
twice a day or 250mg 3 times a day
Severe: 875 mg 2 times a day or 500mg 3 times a day
ear, Nose and Throat (ENT) Infections
Mild/Moderate:
500
mg
2 times a day or 250mg every 8hrs
Severe: 875 mg 2 times a day or else 500mg 3 times a day
Dosage forms and strengths:
Oral solution
125mg per 5ml
200mg per 5ml
250mg per 5ml
400mg per 5ml
Capsule
250mg
500mg
Tablet
500mg
875mg
Tablet, chewable
125mg
250mg
group A Streptococcal (GAS) infections
Children and Adolescents: :
50 mg/kg/day orally daily or in divided doses 2 times a day for 10 days; may be increase up to 1,000 mg/day
ER: 775 mg orally daily for 10 days
ear, Nose and Throat (ENT) Infections
Mild/Moderate:
25
mg/kg
day in divided doses every 12hrs or 20 mg per kg per day in divided doses 3 times a day
Severe: 45 mg/kg per day divided in doses every 12hrs or 40 mg/kg per a day in divided doses every 8hrs
Mild/Moderate:
25 mg/kg per day in divided doses every 12hrs or 20 mg/kg per day in equal divided doses every 8hrs
Severe: 45 mg/kg per day divided in doses every 12hrs or 40 mg/kg per day in divided doses every 8hrs
genitourinary Tract Infections
25 mg/kg per day in divided doses every 12hrs or 20 mg/kg per day in equal divided doses every 8hrs
Severe: 45 mg/kg per day divided in doses every 12hrs or 40 mg/kg per day in divided doses every 8hrs
lower Respiratory Tract Infections
Mild/moderate/severe :
45 mg/kg daily divided in doses for every 12hrs or 40 mg/kg per day in divided doses for every 8hrs
may enhance the serum concentration
may diminish the excretion rate of amantadine
may enhance the concentration when combined with serum of selexipag
may enhance the concentration of serum when combined with treprostinil
When amoxicillin combines with doxycycline it decreases the effects of action of drug by antagonism effect.
When amoxicillin combines with eravacycline it decreases the effects of action of drug by antagonism effect.
When amoxicillin combines with minocycline it decreases the effects of action of drug by antagonism effect.
When amoxicillin combines with mycophenolate it decreases the effects of action of drug and it may result impairment of enterohepatic recirculation.
When amoxicillin combines with omadacycline it decreases the effects of action of drug by antagonism effect
When amoxicillin combines with pexidartinib it decreases the effects of action of drug and results in hepatotoxicity.
When amoxicillin combines with pretomanid it decreases the effects of action of drug and results in hepatotoxicity.
When amoxicillin combines with sarecycline it decreases the effects of action of drug by antagonism effect.
When amoxicillin combines with tetracycline it decreases the effects of the action of drug by antagonism effect.
When amoxicillin combines with typhoid vaccine it decreases the effects of action of vaccine by antagonism effect.
When amoxicillin combines with BCG vaccine it decreases the effects of action of vaccine by antagonism effect.
When both drugs are combined, there may be a reduced therapeutic effect of amoxicillin
When both drugs are combined, there may be a decrease in levels of minocycline by inhibition of GI absorption
when both drugs are combined, there may be a reduced effect of amoxicillin
when both drugs are combined, there may be a decreased effects of amoxicillin
tetracycline may decrease the therapeutic effects of penicillins by interfering with its bactericidal effects
tetracycline may decrease the therapeutic effects of penicillins by interfering with its bactericidal effects
may enhance the concentration of serum when combined with CYP2C8 substrates
When amoxicillin combines with allopurinol it decreases the effects of the drug by resulting hypersensitivity reaction.
When amoxicillin combines with aspirin it decreases the effects of action of drug by plasma binding protein and results in lowering of renal clearance.
When amoxicillin combines with aspirin citric acid it decreases the effects of the action of drug and results in lowering of renal clearance.
When amoxicillin combines with bazedoxifene it decreases the effects of action of drug and results in changes of intestinal flora.
Choline magnesium Trisalicylate
When amoxicillin combines with choline magnesium tri salicylate it decreases the effects of action of drug by plasma binding protein and results in lowering of renal clearance.
When amoxicillin combines with dienogest it decreases the effects of action of drug and results in changes of intestinal flora.
When amoxicillin combines with ethinylestradiol it decreases the effects of action of the drug and results in changes of intestinal flora.
When amoxicillin combines with hydrochlorothiazide it decreases the effects of the action of drug by decreasing renal clearance.
When amoxicillin combines with levonorgestrel oral it decreases the effects of action of the drug and results in changes of intestinal flora.
When amoxicillin combines with mestranol it decreases the effects of action of the drug.
When amoxicillin combines with methotrexate it decreases the effects of the action of drug by decreasing renal clearance.
When amoxicillin combines with methyclothiazide it decreases the effects of the action of drug by decreasing renal clearance.
When amoxicillin combines with metolazone it decreases the effects of the action of drug by decreasing renal clearance.
When amoxicillin combines with rose hips it decreases the effects of the action of drug by decreasing renal clearance.
When amoxicillin combines with salicylates it decreases the effects of action of drug by plasma binding protein and results in lowering of renal clearance.
When amoxicillin combines with salsalate it decreases the effects of action of drug by plasma binding protein and results in lowering of renal clearance.
When amoxicillin combines with sodium phenylacetate it decreases the effects of the action of drug by decreasing renal clearance.
When amoxicillin combines with metolazone it decreases the effects of the action of drug and results in changing metabolism.
When amoxicillin combines with sulfasalazine it decreases the effects of action of drug by plasma binding protein and results in lowering of renal clearance.
When amoxicillin combines with warfarin it decreases the effects of the action of drug by increasing bleeding and results in renal and liver impairment.
antipyrine has the potential to reduce the rate of excretion of amoxicillin, leading to a potential elevation in the serum levels
acemetacin may increase the serum concentration of penicillins
penicillins may iincrease the anticoagulant effect of Vitamin K Antagonists
penicillins may decrease serum concentrations of the active metabolite(s) of mycophenolate
may diminish the serum concentration when combined with CYP2C8 substrates
allopurinol: they may increase the potential for allergic or hypersensitivity reactions to amoxicillin
may enhance the concentration of serum when combined with treprostinil
daprodustat: they may enhance the serum concentration of CYP2C8 Inhibitors
CYP2C8 Inhibitors: they may enhance the serum concentration of repaglinide
When amoxicillin combines with amiloride it decreases the effects of the action of drug by increasing GI absorption.
When amoxicillin combines with azithromycin it decreases the effects of action of drug by antagonism effect.
When amoxicillin combines with aztreonam it decreases the effects of action of drug by synergestic effect.
When amoxicillin combines with chloramphenicol it decreases the effects of the action of drug by antagonism effect.
When amoxicillin combines with clarithromycin it decreases the effects of action of drug by antagonism effect.
When amoxicillin combines with erythromycin ethyl succinate it decreases the effects of action of drug by antagonism effect.
When amoxicillin combines with erythromycin lactobionate it decreases the effects of action of drug by antagonism effect.
When amoxicillin combines with erythromycin stearate it decreases the effects of action of drug by antagonism effect
When amoxicillin combines with pyridoxine it decreases the effects of action of the drug and results in changes of intestinal flora.
probenecid has the potential to elevate the concentration serum of Beta-lactamase Inhibitors
Adverse reactions:
Frequency defined:
1% to 10%
Allergy
Anaphylactic shock
Contact dermatitis
Rash
1% to 1.7%
Diarrhea
Nausea
Headache
0.1% to 0.7% (very rare)
Vomiting
Abdominal pain
Frequency not defined:
Angioedema
Anxiety
Bullous rash
C. difficile-associated diarrhea
Convulsions
Dizziness
Erythema multiforme
Exfoliative dermatitis
Hypersensitivity vasculitis
Insomnia
Maculopapular rash with erythema
Mucocutaneous candidiasis
Pseudomembranous colitis
Toxic epidermal necrolysis
Serum sickness
Stevens Johnson Syndrome
Urticaria
Note: Adverse reactions like urticaria, skin rashes and serum sickness can be controlled by antihistamines drugs. If these reactions occur, the intake of amoxicillin needs to be discontinued. The immediate use of intravenous steroids, oxygen, and epinephrine treatment is required for serious anaphylactic reactions.
Contraindication:
The contraindication includes a history of hypersensitivity to any penicillin. Therefore, screening is needed for renal and hepatic function.
Cautions
Pregnancy
Category B.
The class penicillin drugs which are acceptable for the use in pregnancy women are used for different infections. As per the clinical studies, in pregnant women the use of amoxicillin has not found any amoxicillin exposure during pregnancy, birth defects, miscarriage and outcomes of fetal.
Lactation:
Recent studies state that low levels of amoxicillin are present in breast milk and the relative infant dose (RID) range is calculated 1% for amoxicillin. The range of RID less than 10% is always compatible for breast feeding. In breast fed infants the amoxicillin will not cause any adverse reactions.
Patient information leaflet
Generic Name: amoxicillin
Why do we use amoxicillin?
Amoxicillin is a drug for the treatment of various bacterial infections. It comes under the penicillin type of antibiotic class. It acts as bacteriostatic by stopping the growth of bacteria.
It is ineffective in viral infections, and when antibiotics are used irrationally without requirement, they may cause antibiotic resistance. They would become ineffective in treating future infective conditions in the body.
The dose is administered orally once daily after a meal as per the directions by the physician. Do not chew/crush the extended or controlled-release tablets. Splitting or mutilating the pills is also prohibited.
During the antibiotics treatment, patients should take plenty of water and fluids. Continue the use of medications as prescribed, do not discontinue or continue without the doctor’s permission.
Side effects may include diarrhea, vomiting, nausea, oral thrush, or vaginal infections.
The drug interactions for the same are provided in the different sections herein. Store the medication at room temperature and away from sunlight/moisture. It is also advised to keep the product away from pets and children.
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