- March 15, 2022
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Brand Name :
Ziagen
Synonyms :
abacavir
Class :
Antiretroviral Agents; NRTIs
Dosage Forms & Strengths
Solution, Oral
20 mg/ml (240 ml)
Tablet, Oral
300 mg
300 mg oral tablet twice a day
Or
600 mg oral tablet once a day
Note: used in combination with other antiretroviral agents
Dosage Forms & Strengths
Solution, Oral
20 mg/ml (240 ml)
Tablet, Oral
300 mg
Infants >3 years to adolescents:
Dose instructions based on weight:
14 to <20kg: 150 mg orally twice daily
20 to <25 kg: 150 mg orally in the morning and 300 mg orally in the evening
>25 kg 300 mg orally every 12 hours
Refer to adult dosing
may decrease the therapeutic effect when combined
may increase the risk of adverse effect of other reverse transcriptase inhibitors
may increase the risk of adverse effect of other reverse transcriptase inhibitors
may increase the risk of adverse effect of other reverse transcriptase inhibitors
may increase the risk of adverse effect of other reverse transcriptase inhibitors
may increase the risk of adverse effect of other reverse transcriptase inhibitors
it decreases the rate of elimination of pidotimod
may increase the risk of adverse effect of other reverse transcriptase inhibitors
may increase the risk of adverse effect of other reverse transcriptase inhibitors
may increase the risk of adverse effect of other reverse transcriptase inhibitors
may increase the risk of adverse effect of other reverse transcriptase inhibitors
may increase the risk of adverse effect of other reverse transcriptase inhibitors
reverse transcriptase inhibitors increase the concentration of ergonovine in the serum
may diminish the serum concentration of each other when combined
it may diminish the excretion rate when combined with permethrin, resulting in an enhanced serum level
The Therapeutic effectiveness of abacavir may be reduced by methadone
cefotiam might lead to a reduction in the rate of excretion of abacavir, potentially leading to elevated serum levels
it may diminish the excretion rate when combined with gadofosveset, resulting in an enhanced serum level
aminophenazone has the potential to reduce the rate of excretion of abacavir, leading to an elevation in its concentration serum
abacavir Might lead to a reduction in the rate of excretion of triethylenetetramine, potentially leading to elevated levels of serum
meticrane has the potential to enhance the rate of excretion of abacavir; this can potentially lead to decreased levels of serum, possibly diminishing its effectiveness
abacavir has the potential to reduce the rate of excretion of idebenone, leading to an elevation in levels of serum
it decreases the concentration of antiretroviral agent in the serum
may diminish the tiopronin excretion rate
Actions and Spectrum:
abacavir is an antiretroviral medication used in the treatment of human immunodeficiency virus (HIV) infection. It belongs to the class of drugs known as nucleoside reverse transcriptase inhibitors (NRTIs). Here are the actions and spectrum of abacavir:
Action:
Spectrum:
Frequency defined
>10%
Skin rash
Vomiting
Bronchitis
Cough
Upper respiratory tract infection
Fever
1% to 10%
Acute myocardial infection
Cardiac failure
Coronary artery disease
Coronary occlusion
Endocarditis
Hypertension
Ischemic heart disease
Portal vein thrombosis
Septic shock
Unstable angina pectoris
Acne vulgaris
Alopecia
Folliculitis
Nail disease
Pruritis
Sweat gland disease
Lipodystrophy
Frequency not defined
Hepatitis
Hepatotoxicity
Immune reconstitution syndrome
Post-marketing
Stevens-Johnson syndrome
Toxic epidermal necrolysis
Drug rash with eosinophilia
Pregnancy consideration: Abacavir may transfer in moderate to high amounts across the human placenta.
Lactation: excretion of abacavir in breast milk is not known.
Pregnancy category:
Patient information leaflet
Generic Name: abacavir
Why do we use abacavir?
abacavir is used in the treatment of human immunodeficiency virus (HIV) infection for several reasons:
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