- March 15, 2022
- Newsletter
- 617-430-5616
Menu
Menu
Menu
Menu
Menu
Menu
Brand Name :
APO-Cefaclor, CO Cefaclor, DOM-Cefaclor
Synonyms :
Class :
Antibiotics & Cephalosporins (second generation)
Dosage forms & Strengths
Capsule, Oral
250 mg
500 mg
Suspension Reconstituted, Oral:
125 mg/5ml (150ml)
250 mg/5ml (150ml)
375 mg/5ml (100ml)
Extended-release Tablet, Oral:
500 mg
General dosage, oral:
250 to 500 mg immediate-release tablet q8hours
500 mg extended-release tablet q12hours
Acute Chronic bronchitis:
500 mg extended-release tablet q12hours for 7 days
Pneumonia, empiric therapy:
500 mg immediate-release tablet q8hours for a minimum of 5 days (extended the therapy duration as per vital signs)
Streptococcal pharyngitis:
250 mg immediate-release tablet q8hours for 10 days (alternative for patients allergic to penicillin)
Urinary tract infection:
250 mg immediate-release tablet q8hours for 5 to 7 days (used only if first-line beta-lactams cannot be used)
Dose adjustments:
Hemodialysis, peritoneal dialysis: do not administer during dialysis, administer after dialysis
For mild to severe kidney impairment: no dosage adjustment indicated
Hepatic impairment: no dosage adjustment provided
500
mg
Orally
every 12 hrs
7
days
Tablet
500
mg
Orally
every 8 hrs
5
days
Tablet
Extend the therapy duration as per vital signs
250
mg
Orally
every 8 hrs
10
days
Tablet
It is used as an alternative for patients allergic to penicillin
250
mg
Orally
every 8 hrs
5 - 7
days
Tablet
Cefaclor can be used only if first-line beta-lactams cannot be used
Dosage forms & Strengths
Capsule, Oral
250 mg
500 mg
Suspension Reconstituted, Oral:
125 mg/5ml (150ml)
250 mg/5ml (150ml)
375 mg/5ml (100ml)
Extended-release Tablet, Oral:
500 mg
General dosage, oral:
Infants, children and adolescents: 20-40 mg/kg/day immediate-release tablet divide q8hours (do not exceed 1500 mg/day)
Bronchitis: Adolescents >16 years
Acute bacterial infection: 500 mg extended-release tablet b.i.d for 7 days q12hours
Lower respiratory tract infections:
Infants, children and adolescents: 20-40 mg/kg/day immediate-release tablet divide q8hours (do not exceed 1500 mg/day)
Otitis infection: Infants, children, and adolescents
40 mg/kg/day immediate-release tablet divided q8hours (do not exceed 1000 mg/day)
Pharyngitis: Infants, children, and adolescents
20 mg/kg/day immediate-release oral suspension/capsule divided q8hours (do not exceed 1000 mg/day)
Skin infection: Infants, children, and adolescents
20-40 mg/kg/day immediate-release divided q8hours (do not exceed 1000 mg/day)
Urinary tract infection: Infants, children, and adolescents
20-40 mg/kg/day immediate-release divided q8hours (do not exceed 1000 mg/day)
Dose adjustment:
No dosage adjustment was provided for GFR >10 ml/minute/1.73 m2
50% of the dose recommended for GFR >10 ml/minute/1.73 m2
50% of the dose recommended for ERD
20 - 40
mg/kg
Orally
every 8 hrs
Tablet
do not exceed the dose above 1000 mg/day
the interaction decreases the therapeutic effects of the vaccine
the interaction decreases the therapeutic effects of the vaccine
the interaction decreases the therapeutic effects of the vaccine
bazedoxifene conjugated estrogens
cefaclor may reduce the therapeutic effects of oral forms of conjugated estrogen by altering gut microflora
cefaclor will reduce the therapeutic effects of oral forms of hormones by altering gut microflora
cefaclor will reduce the therapeutic effects of oral forms of hormones by altering gut microflora
furosemide may enhance the therapeutic effects of cefaclor
the interaction may increase the therapeutic effects of cefaclor
the interaction may increase the therapeutic effects of cefaclor
cefaclor reduces the therapeutic effects of sodium picosulfate by altering metabolism
cephalosporins may decrease serum concentration and enhance nephrotoxicity of aminoglycosides
enhance the serum drug concentration by reducing renal clearance
enhance the serum drug concentration by reducing renal clearance
may raise the risk of nephrotoxicity
cefaclor increases the anticoagulant activity of warfarin by an unknown mechanism
it may diminish the excretion rate when combined with estradiol valerate resulting in a greater serum level
it increases the nephrotoxicity of cephalosporins
cefaclor increases the serum concentration of other drugs by reducing renal clearance
cefaclor increases the serum concentration of other drugs by reducing renal clearance
cefaclor increases the serum concentration of other drugs by reducing renal clearance
the interaction reduces the effects of cefaclor
cefaclor increases the therapeutic effects of cyclopenthiazide
cefaclor increases the serum concentration of other drugs by reducing renal clearance
cefaclor will increase the effects of sulfasalazine
Frequency defined:
>10%: For IV
Fever
Fatigue
Headache
Vomiting
Nausea
Rash
For oral:
Headache
Lymphopenia
Hypersensitivity
Upper respiratory tract infection
1-10%
Diarrhea
Insomnia
Bronchitis
Depression
Alopecia
Arthritis
Back pain
<1%:
pneumonia
Pancytopenia
Seizures
Fungal infection
Hemolytic anemia
Cellulitis
Pregnancy consideration: cefaclor is assigned under pregnancy category C. It should be used with caution for pregnant women.
Lactation: No data available for excretion in breast milk, it should be avoided due to potential side effects.
Pregnancy category:
Patient information leaflet
Generic Name: Cefaclor
Pronounced: SEFF-uh-klor
Why do we use cefaclor?
Cefaclor is a second-generation cephalosporin antibiotic drug. It is used to treat bacterial infections, which kill bacteria by inhibiting bacterial cell wall synthesis.
ADVERTISEMENT
Founded in 2014, medtigo is committed to providing high-quality, friendly physicians, transparent pricing, and a focus on building relationships and a lifestyle brand for medical professionals nationwide.
USA – BOSTON
60 Roberts Drive, Suite 313
North Adams, MA 01247
INDIA – PUNE
7, Shree Krishna, 2nd Floor, Opp Kiosk Koffee, Shirole Lane, Off FC Road, Pune 411004, Maharashtra
Founded in 2014, medtigo is committed to providing high-quality, friendly physicians, transparent pricing, and a focus on building relationships and a lifestyle brand for medical professionals nationwide.
MASSACHUSETTS – USA
60 Roberts Drive, Suite 313,
North Adams, MA 01247
MAHARASHTRA – INDIA
7, Shree Krishna, 2nd Floor,
Opp Kiosk Koffee,
Shirole Lane, Off FC Road,
Pune 411004, Maharashtra
