Mechanism of action
lisinopril is an angiotensin-converting enzyme (ACE) inhibitor that blocks the conversion of Angiotensin I to Angiotensin II, a potent vasoconstrictor. By inhibiting the renin-angiotensin-aldosterone system, lisinopril causes vasodilation, which results in a decrease in blood pressure. lisinopril also reduces the workload on the heart, making it helpful in treating heart failure
hydrochlorothiazide is a thiazide diuretic that increases the excretion of sodium and chloride ions in the urine. This causes a decrease in the volume of fluid in the blood vessels, which reduces blood pressure. hydrochlorothiazide also has mild vasodilatory effects, further contributing to its anti-hypertensive activity
Spectrum
The spectrum of activity of lisinopril and hydrochlorothiazide includes the treatment of hypertension, heart failure, and other cardiovascular conditions. They are also sometimes used in treating kidney disease and diabetes, as they can help protect the kidneys and reduce the risk of complications associated with these conditions
