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Brand Name :
Clinimix E
Synonyms :
amino acids and electrolytes in dextrose with calcium
Class :
Intravenous nutritional products
Brand Name :
Clinimix E
Synonyms :
amino acids and electrolytes in dextrose with calcium
Class :
Intravenous nutritional products
Dosage Forms & Strengths
The patient’s body weight, nutritional and hydration needs, clinical state (ability to metabolize the amino acids and dextrose), and additional energy provided orally or enterally all play a role in determining the appropriate Clinimix E dosage.
There are two-port and three-port container configurations for CLINIMIX E available.
A three-port container has one port for medication, one port for additives, and one port for the outlet.
The patient's body weight, nutritional and hydration needs, clinical state (ability to metabolize the amino acids and dextrose), and additional energy provided orally or enterally all play a role in determining the appropriate Clinimix E dosage.
There are two-port and three-port container configurations for CLINIMIX E available.
A three-port container has one port for medication, one port for additives, and one port for the outlet.
One power port and one medicine port make up the two port containers.
Dosage Forms & Strengths
Safety and efficacy not established
Refer adult dosing
Actions and Spectrum:
amino acids are the building blocks of proteins, contributing to protein synthesis and cellular repair. They are also essential for various physiological processes, including immune function and enzymatic reactions.
Electrolytes, including sodium, potassium, chloride, and others, help maintain cellular membrane potentials and fluid balance and support nerve and muscle function. dextrose (glucose) serves as a primary energy source for cells, providing readily available energy for cellular metabolism. calcium is essential for bone health, blood clotting, muscle contraction, and cellular signaling.
The spectrum of activity is broad, encompassing various aspects of metabolism, cellular function, and nutrient balance. The formulation is often individualized based on the specific needs and clinical condition of the patient.
Frequency not defined
Bloating
Chest pain
Confusion
Dark urine
Anxiety
Blurred vision
Chills
Cough or hoarseness
Black box warning:
None
Contraindications/caution:
Contraindications:
Caution:
Pregnancy consideration: Insufficient data available
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
Pharmacokinetics:
Absorption
amino acids are directly introduced into the bloodstream when administered intravenously, bypassing the gastrointestinal absorption process.electrolytes, including sodium, potassium, chloride, etc., are rapidly absorbed into the bloodstream through the intravenous route.
dextrose (glucose) is quickly absorbed into the bloodstream, providing an immediate energy source.calcium is infused intravenously and directly introduced into the bloodstream.
Distribution
Once in the bloodstream, amino acids are distributed to various tissues and organs, contributing to protein synthesis and cellular functions.electrolytes are distributed in the extracellular and intracellular compartments, maintaining fluid balance and supporting nerve and muscle functions.dextrose is distributed to cells, where it undergoes metabolic processes to produce energy.calcium is distributed in the bloodstream and is tightly regulated to maintain homeostasis, with some being bound to proteins and a small fraction remaining ionized.
Metabolism
amino acids participate in metabolic processes, including protein synthesis and energy production through gluconeogenesis and the citric acid cycle.electrolytes do not undergo significant metabolic transformations but play a regulatory role in various metabolic pathways.
dextrose undergoes glycolysis and cellular respiration to produce ATP, serving as a primary energy source for cells.calcium does not undergo metabolic processes in the same way as energy substrates but participates in various physiological functions.
Elimination and Excretion
Excess amino acids are primarily eliminated through metabolic processes, with nitrogenous waste products excreted via the kidneys as urea. electrolytes are excreted by the kidneys, and their levels are regulated to maintain homeostasis. dextrose is metabolized, and the byproducts are excreted through various pathways, including respiration and urine. calcium is excreted primarily through the kidneys, and its levels are tightly regulated to prevent imbalances.
Administration:
Intravenous administration
The administration of a solution containing amino acids, electrolytes, dextrose, and calcium is typically done intravenously (IV). This intravenous solution is often referred to as Total Parenteral Nutrition (TPN) or parenteral nutrition.
Patient information leaflet
Generic Name: amino acids and electrolytes in dextrose with calcium
Why do we use amino acids and electrolytes in dextrose with calcium?
amino acids and electrolytes in a solution with dextrose and calcium are often used in medical settings for various purposes. Here’s a brief overview of their common uses:
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