Long COVID Patterns in the RECOVER-Adult Study
November 21, 2025
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Brand Name :
Niktimvo
Synonyms :
axatilimab-csfr
Class :
CSF1R Inhibitors, Monoclonal Antibody, Antineoplastics
Brand Name :
Niktimvo
Synonyms :
axatilimab-csfr
Class :
CSF1R Inhibitors, Monoclonal Antibody, Antineoplastics
Adult
Solution
50mg/ml
Chronic Graft-versus-host DiseaseÂ
Administer dose of 0.3 mg/kg through intravenous route for every 2 weeks
Solution
50mg/ml
Chronic Graft-Versus-Host Disease
For ≥40 kg:
Administer dose of 0.3 mg/kg through intravenous route for every 2 weeks
For <40 kg: Safety and efficacy not determined
Chronic Graft-versus-host DiseaseÂ
For ≥40 kg:
Administer dose of 0.3 mg/kg through intravenous route for every 2 weeks
Axatilimab is a monoclonal antibody which targets colony-stimulating factor 1 receptor for monocytes and macrophages.
It targets CSF1R to diminish monocytes and macrophages activity for reduced inflammation.
Frequency defined:
>50%
All grades
Increased AST
Infection
Increased ALT
Decreased phosphate
>10-50%
All grades
Decreased hemoglobin
Viral infection
Anti-axatilimab antibodies
Fatigue
Increased amylase
Increased calcium
Infusion-related reactions
Cough
Bacterial infection
Pyrexia
Increased alkaline phosphatase
Increased GGT
Musculoskeletal pain
Increased lipase
Increased creatine phosphokinase
Nausea
Headache
Dyspnea
Edema
Drug hypersensitivity
Dizziness
Decreased appetite
Grade 3 or 4
Viral infection
Infection
1-10%
All grades
Rash
Grade 3 or 4
Bacterial infection
Diarrhea
Drug hypersensitivity
Increased ALT
Increased lipase
Increased AST
Decreased hemoglobin
Increased GGT
Musculoskeletal pain
Fatigue
Decreased appetite
Nausea
Pyrexia
Edema
Headache
Increased calcium
None
Contraindications:
None
Cautions:
Infusion-related reactions
Embryo-fetal toxicity
Pregnancy category: Â N/A
Lactation: Maternal IgG is present in human milk
Pregnancy categories:
Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester.
Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women.
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.
Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women.
Category N: There is no data available for the drug under this category.
It blocks the signalling pathway to cause the survival, differentiation, and activation of macrophages. The activity of pathogenic macrophages in tissues is decreased due to this drug.
Pharmacodynamics:
CSF1R inhibition decreases pro-inflammatory and pro-fibrotic macrophages to reduce chronic inflammation. It reduces macrophage activity to decrease inflammation and fibrosis that attacks inflammatory cytokines.
Pharmacokinetic:
Absorption:
It is administered through intravenous infusion and there is no systemic accumulation is observed.
Distribution:
The volume of distribution is 6.06 L.
Metabolism:
It is metabolized into small peptides with catabolic pathways.
Excretion and elimination:
It has clearance up to 0.07 L/hr.
It is administered intravenously in the injection form.
Generic Name: axatilimab-csfr
Why do we use axatilimab-csfr?
Axatilimab-csfr it is indicated in treatment of Graft-Versus-Host Disease.
It shows early positive results for cGVHD symptoms in refractory patients.
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