World’s First Human Implant of a 3D-Printed Cornea Restores Sight
December 15, 2025
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
Regranex Gel
Synonyms :
becaplermin
Class :
Metabolic and Endocrine, Wound Care
Brand Name :
Regranex Gel
Synonyms :
becaplermin
Class :
Metabolic and Endocrine, Wound Care
Dosage Forms & StrengthsÂ
Topical gelÂ
0.01%Â
The formula in inches based on tube size as follows:
For 2 g tube: Length of ulcer Ă— width Ă— 1.3 is equal to length of gel in inches
For 15 g tube: Length of ulcer Ă— width Ă— 0.6 is equal to length of gel in inches
The formula in centimeters based on tube size as follows:
For 2 g tube: Length of ulcer Ă— width Ă· 2 is equal Length of gel in cm
For 15 g tube: Length of ulcer Ă— width Ă· 4 is equal to length of gel in cm
Dosing Considerations
In treatment of venous stasis ulcers and pressure ulcers the efficacy is not determined
In humans the effects on exposed joints, bone, tendons and ligaments are not established
Safety and efficacy not determined Â
Refer to adult dosingÂ
Actions and SpectrumÂ
becaplermin works by stimulating the migration and proliferation of cells involved in wound healing. It stimulates the production of fibroblasts, endothelial cells, and granulation tissue, which are essential for wound healing processes. The spectrum of becaplermin is focused on the treatment of chronic, non-healing diabetic ulcers.
Frequency defined
<1%
Ulcer infection
Local pain
Tunneling of ulcer
Skin ulceration
1-10%
Skin rash
Erythema
Post marketing Reports
Burning sensation at site of application
None
Contraindication:Â
Caution:Â
Pregnancy consideration:Â
Pregnancy category: N/AÂ
Lactation: Excretion into human milk is unknown Â
Pregnancy Categories:        Â
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.Â
Category N: There is no data available for the drug under this category.Â
Pharmacology Â
becaplermin should not be applied to wounds that show signs of clinically significant infections. It stimulates the production of granulation tissue and encourages the chemotactic recruitment and proliferation of cells involved in wound healing.Â
PharmacodynamicsÂ
Human platelet-derived growth factor (rPDGF-BB), which encourages fibroblast proliferation and differentiation to speed up wound healing and accelerates the development of new granulation tissue, also stimulates angiogenesis.Â
PharmacokineticsÂ
Absorption  Â
The absorption of becaplermin through intact skin is minimal. Â
DistributionÂ
It does not distribute extensively throughout the body. Â
MetabolismÂ
Not known Â
Elimination and excretionÂ
Not known Â
becaplermin is administered topically as a gel directly to the surface of the chronic and non-healing diabetic ulcer.
Generic Name: becaplerminÂ
Why do we use becaplermin?Â
becaplermin is used for the treatment of chronic, non-healing diabetic ulcers. Â
It is typically used as an adjunctive therapy alongside measures such as wound debridement and infection control.
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
