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Brand Name :
ORAFLEX
Synonyms :
benoxaprofen (discontinued)
Class :
Anti-inflammatory drug
Brand Name :
ORAFLEX
Synonyms :
benoxaprofen (discontinued)
Class :
Anti-inflammatory drug
Dosage forms and strengths
Oral tablet
600 mg
800 mg
Take 600 mg a day orally
In some cases the dose may be elevated to 800 mg
Take 600 mg a day orally
In some cases the dose may be elevated to 800 mg
Not indicated
Refer adult dosing
the risk of bleeding can be raised when benoxaprofen is combined with sulfinpyrazone
the severity of hypertension may be increased
Action and Spectrum
It relieves pain and inflammation by blocking the production of prostaglandins, which are chemicals that promote these symptoms. It is used to treat osteoarthritis and rheumatoid arthritis, but it is discontinued due to severe side effects.
Frequency not defined
Urinary urgency
Blurred vision
Epistaxis
Palpitations
Headache
Dizziness
Faintness
Black Box Warning:
None
Contraindication/Caution:
Hypersensitivity
Renal impairment
Hepatic impairment
Pregnancy warnings:
Pregnancy category: N/A
Lactation: Excreted into human milk is unknown
Pregnancy Categories:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology
It is used for ain-relieving, anti-swelling, and fever-reducing abilities, belongs to the category of non-steroidal anti-inflammatory drugs.
Pharmacodynamics
It inhibits the cyclooxygenase activity which is responsible for the synthesis of prostaglandins.
Pharmacokinetics
Absorption
Limited data available
Distribution
Limited data available
Metabolism
Limited data available
Elimination/Excretion
Limited data available
Administration
It is administered orally in the form of tablets or capsules.
Patient information leaflet
Generic Name: benoxaprofen (discontinued)
Why do we use benoxaprofen (discontinued)?
IT is used treat pain and inflammation associated with Osteoarthritis and Rheumatoid arthritis.
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