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Brand Name :
Vascor
Synonyms :
bepridil
Class :
Calcium Antagonists
Brand Name :
Vascor
Synonyms :
bepridil
Class :
Calcium Antagonists
Dosage Forms & Strengths
Not available
Initially, 200 mg each day
After 10 days, increase the dose to 300 mg each day if required
No data is available
Refer to the adult dosing
Dose reduction may be required
when both drugs are combined, there may be an increased risk or severity of QTC prolongation
it may enhance the risk of QTc prolongation when combined with amifampridine
When bepridil is used together with fluconazole, this leads to reduction in the bepridil metabolism
When ponesimod is used together with bepridil, this leads to enhanced risk or seriousness of bradycardia
When bepridil is used together with givinostat, this leads to enhanced risk or seriousness of Qtc prolongation
buflomedil may lessen Bepridil's antihypertensive effects
When indisulam is used together with bepridil, this leads to a reduction in bepridil metabolism
bepridil: it may increase the arrhythmogenic activities of lidoflazine
bepridil the therapeutic efficacy of bepridil may be decreased when used in combination with polmacoxib
bepridil: it may decrease the metabolism of piperazine
when both drugs are combined, there may be an increased risk or severity of adverse effects
the rate of metabolism of dihydrocodeine may be reduced
the antihypertensive activity of bepridil may be reduced
the risk of QTc prolongation may be increased
the rate of metabolism of bepridil may be reduced
the therapeutic activity of bepridil may be reduced
the antihypertensive activity of bepridil may be reduced
the antihypertensive activity of bepridil may be reduced
When bepridil is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
Actions and Spectrum:
Actions:
bepridil exerts pharmacological effects by inhibiting calcium ion influx into cardiac and smooth muscle cells. It achieves this by blocking specific types of calcium channels, mainly the L-type calcium channels.
By inhibiting calcium influx into cardiac muscle cells, bepridil reduces the entry of calcium ions during the stagnant phase of the cardiac action potential. This results in a decrease in myocardial contractility, a reduction in the heart rate, and dilation of coronary arteries. These actions help lower the heart’s oxygen demand, making it helpful in treating angina pectoris.
Spectrum:
bepridil is used to treat chronic stable angina pectoris (chest pain) in patients with coronary artery disease when other treatments are not sufficient or are contraindicated.
bepridil is used to manage certain cardiac arrhythmias, including ventricular arrhythmias, where it can help stabilize the heart’s electrical activity.
Frequency not defined
dizziness
bradycardia
edema
nausea
dyspnea
palpitations
headache
drowsiness
QT prolongation
CHF
nervousness
rash
weakness
psychiatric disturbances
insomnia
tremor
sexual dysfunction
GI disturbances
tinnitus
rhinitis
paraesthesia
blurred vision
dyspnoea
diaphoresis
akathisia
cough
flu syndrome
Black Box Warning:
None
Contraindication/Caution:
Contraindications:
Cautions:
Pregnancy consideration:
It is contraindicated during pregnancy.
Breastfeeding warnings:
No data is available.
Pregnancy category:
Pharmacology:
bepridil exerts its pharmacological effects by blocking L-type calcium channels in cardiac and smooth muscle cells. These channels are responsible for the entry of calcium ions into the cells during depolarization, which is essential for muscle contraction.
By inhibiting calcium influx through these channels, bepridil reduces myocardial contractility (the force of the heart’s muscular contractions). This results in decreased oxygen demand by the heart, making it helpful in treating angina pectoris, especially in cases where other treatments are insufficient or contraindicated.
Pharmacodynamics:
By inhibiting calcium influx through these channels, bepridil reduces the entry of calcium ions into cardiac muscle cells during the stagnant phase of the cardiac action potential. This leads to a reduction in myocardial contractility (the force of the heart’s muscular contractions), which results in decreased oxygen demand by the heart.
Pharmacokinetics:
Absorption
bepridil is administered orally, typically in the form of tablets or capsules. After oral ingestion, the drug is absorbed from the gastrointestinal tract into the bloodstream. The rate and extent of absorption may vary among individuals.
Distribution
bepridil is distributed throughout the body, including the heart and other tissues. Due to its lipophilic nature, it can cross cell membranes and enter various organs and tissues. The drug’s distribution is influenced by blood flow to different tissues and protein binding in the bloodstream.
Metabolism
bepridil undergoes extensive metabolism in the liver. The primary metabolic pathway involves cytochrome P450 (CYP) enzymes, particularly CYP3A4. The drug is metabolized into several metabolites, some of which may also have pharmacological activity.
Elimination and Excretion
The elimination of bepridil and its metabolites occurs mainly through the kidneys. The drug and its metabolites get excreted in the urine. The elimination half-life of bepridil is relatively long, ranging between 20 to 40 hours.
Administration
bepridil is administered orally, taking the form of tablets or capsules.
Patient information leaflet
Generic Name: bepridil
Why do we use bepridil?
bepridil was used to manage chronic stable angina pectoris, a condition characterized by chest pain or discomfort by the reduction of blood flow to the heart muscle.
By blocking calcium channels, bepridil reduces the force of the heart’s muscular contractions, lowering the heart’s oxygen demand and relieving chest pain.
It is also prescribed for treating certain cardiac arrhythmias, particularly those involving irregular heart rhythms. Its action on calcium channels can help stabilize the heart’s electrical activity.
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