Action and Spectrum

Actions and Spectrum 

lidoflazine exerts its antiarrhythmic effects by blocking sodium channels in cardiac cells. It reduces the influx of sodium ions during an action potential, which helps stabilize the electrical activity of the heart and prevents abnormal rhythms from occurring.

Drug Interaction

Adverse Reaction

Frequency not defined  

None 

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• lidoflazine should not be used in individuals who have a known hypersensitivity or allergy to the drug or its components. 
• lidoflazine may be contraindicated in individuals with severe congestive heart failure. 

Caution: 

• Caution required in individuals with pre-existing bradycardia. 
• Caution should be taken when using lidoflazine in individuals with significant electrolyte imbalances. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

lidoflazine has mild beta-adrenergic receptor-blocking effects. This action can reduce the effects of sympathetic stimulation on the heart, potentially leading to a decrease in heart rate and contractility. 

Pharmacodynamics 

Limited information available  

Pharmacokinetics 

ADME is not fully understood  

Adminstartion

Administration 

lidoflazine is available in oral tablet form. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: lidoflazine 

Why do we use lidoflazine? 

lidoflazine is used to treat angina, a condition that causes chest pain due to reduced blood flow to the heart.  

lidoflazine also used in ventricular arrhythmia, which are abnormal heart rhythms that can be dangerous.