berdazimer sodium

Action and Spectrum

Actions and spectrum:  

Actions:  

The body makes nitric oxide for immune defense and fights microbes by influencing cytokines, apoptosis, and inflammation through protein nitrosylation. It can also hinder viral replication by generating reactive oxygen and nitrogen molecules. 

Spectrum:  

Berdazimer sodium treats apoptosis, acts as an antibacterial, and has immunomodulatory and anti-inflammatory actions. 

Drug Interaction

Adverse Reaction

>10%  

Pain at the site of application (12.3%)  

 1-10%  

Erythema at application site (6%)  

Exfoliation at application site (2.8%)  

Dermatitis at application site (2.8%)  

Pruritis at application site (3.9%)  

<1%  

Irritation (0.4%)  

Pyrexia (0.7%)  

Infections of the upper respiratory tract (0.7%)  

Vomiting (0.5%)  

Black Box Warning

Black Box Warning  

None 

Contraindication / Caution

Contraindication/Caution:  

Contraindication:  

None  

Caution:  

Allergic contact dermatitis  

Pregnancy / Lactation

Pregnancy consideration:   

Data not available  

Lactation:   

Data not available  

Pregnancy category:   

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.  

Category B: There was a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.    

Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.     

Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.     

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology:  

Berdazimer sodium is a new topical gel releasing nitric oxide, potentially with antiviral effects by interfering with viral enzymes & viral reproduction. 

Pharmacodynamics:  

It releases nitric oxide where applied, possibly inhibiting viral replication by interacting with viral enzymes, hindering virus spread due to its small size. 

Pharmacokinetics:  

Limited data is available  

Adminstartion

Administration:  

Apply berdazimer sodium gel one time a day on affected skin lesions and wash hands thoroughly afterward. 

Patient Information Leaflet

Patient information leaflet  

Generic Name: berdazimer sodium   

Why do we use berdazimer sodium?  

Berdazimer sodium is the first drug approved for treating Molluscum contagiosum and acne vulgaris.