beta carotene, vitamin c, vitamin e, minerals, lutein, eicosapentaenoic acid, docosahexenoic acid and vit b12

Action and Spectrum

Actions and spectrum: 

beta Carotene: 

• Action: beta carotene is a precursor to vitamin A. It is converted to vitamin A in the body as needed. 
• Spectrum: beta carotene supports vision, immune function, and overall skin health. 

Vitamin C: 

• Action: Vitamin C is a water-soluble antioxidant that plays a role in synthesis of collagen and immune function. 
• Spectrum: Vitamin C supports the immune system, skin health, and acts as an antioxidant to neutralize free radicals. 

Vitamin E: 

• Action: Vitamin E is a fat-soluble antioxidant that helps protect cell membranes from oxidative damage. 
• Spectrum: Vitamin E supports cell health and helps maintain cardiovascular health by preventing the oxidation of LDL cholesterol. 

Minerals: 

• Action: Zinc and selenium are essential minerals involved in various enzymatic reactions, immune function, and antioxidant defense. 
• Spectrum: These minerals support immune health; help protect cells from oxidative stress and plays a role in DNA synthesis and repair. 

lutein: 

• Action: lutein is a carotenoid antioxidant that is particularly beneficial for eye health. 
• Spectrum: lutein is known to support vision and may help to reduce the risk of macular degeneration and cataracts. 

eicosapentaenoic acid and docosahexaenoic acid: 

• Action: EPA and DHA are omega-3 fatty acids found in fish oil. They have anti-inflammatory properties and are crucial for brain and heart health. 
• Spectrum: EPA and DHA support cardiovascular health, brain function, and may reduce inflammation in the body. 

Vitamin B12: 

• Action: Vitamin B12 is essential for nerve function, DNA synthesis, and red blood cells production. 
• Spectrum: Vitamin B12 is crucial for maintaining energy levels, cognitive function, and overall neurological health. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Nausea 

Itching 

Exfoliation 

Irritability 

Hepatic impairment 

Vomiting 

Dermatitis 

Alopecia 

Anorexia 

Anaphylactic shock 

Renal calculi 

pain at injection site 

Oxaluria 

Fatigue 

Headache 

Diarrhoea 

Flatulence 

Blurred vision 

Loose stools 

Belching 

Hyperlipidaemia 

Constipation 

Black Box Warning

Black Box Warning: 

there were no specific black box warnings associated with beta carotene, vitamin c, vitamin e, minerals, lutein, eicosapentaenoic acid, docosahexenoic acid and vit b12 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• Allergies and Sensitivities: Individuals who are known to be allergic or hypersensitive to any of the components in this combination should avoid it.  
• Medication Interactions: Some components, such as EPA and DHA (omega-3 fatty acids), may interact with blood-thinning medications like warfarin or aspirin, potentially increasing the risk of bleeding. People taking such medications should consult with their healthcare provider before using this combination. 
• Hemochromatosis: Hemochromatosis is a condition characterized by excess iron absorption and can lead to iron overload. Some mineral supplements, including iron, may not be suitable for individuals with this condition. 
• Children and Adolescents: The use of certain supplements and components in this combination may not be suitable for children and adolescents without proper guidance from a healthcare provider.

Caution: 

• Individual Sensitivities: Individuals may have individual sensitivities or allergies to any of the components, so it is essential to monitor for adverse reactions and discontinue use if any unusual symptoms occur. 
• Iron Absorption: Some minerals, like iron, can interfere with the absorption of other minerals when taken together. Consider the timing of mineral supplements if you are taking them alongside this combination. 
• Liver Disease: Individuals with liver disease should be cautious with high-dose supplements, as the liver plays a role in processing many vitamins and minerals. Consult with a healthcare provider for appropriate dosages. 
• Kidney Disease: High doses of certain minerals, such as potassium or phosphorus, may be contraindicated in individuals with advanced kidney disease.

Comorbidities: 

• Cardiovascular Disease: Some components like EPA and DHA (omega-3 fatty acids) may benefit individuals with cardiovascular disease by helping to reduce triglyceride levels and inflammation. 
• Diabetes: Vitamin C and certain minerals like chromium may support individuals with diabetes by helping to regulate blood sugar levels. 
• Gastrointestinal Conditions: Some components, like vitamin C, may support individuals with gastrointestinal conditions by promoting tissue healing. 
• Thyroid Disorders: Selenium is essential for thyroid function, but excessive supplementation can affect thyroid hormone levels.  
• Eye Conditions: Lutein is known for its potential benefits in supporting eye health, particularly in conditions like age-related macular degeneration. 

Pregnancy / Lactation

Pregnancy consideration: pregnancy category: not assigned 

Lactation: excreted into human milk: unknown   

Pregnancy category: 

• Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 
• <b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 
• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   
• Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 
• Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology: 

The pharmacology of the combination of beta carotene, Vitamin C, Vitamin E, Minerals (such as zinc and selenium), Lutein, Eicosapentaenoic Acid (EPA), Docosahexaenoic Acid (DHA), and Vitamin B12 encompasses a broad spectrum of actions. Vitamin C is a water-soluble antioxidant vital for collagen synthesis and immune function. Vitamin E, a fat-soluble antioxidant, protects cell membranes.

Minerals like zinc and selenium aid enzymatic reactions and immune health. Lutein supports eye health, while EPA and DHA offer anti-inflammatory benefits, cardiovascular support, and cognitive function. Vitamin B12 is essential for nerve & red blood cell function. This combination addresses oxidative stress, immune support, cardiovascular health, vision, and overall well-being.  

Pharmacodynamics: 

• Antioxidant Activity: beta carotene, Vitamin C, Vitamin E, Selenium act as antioxidants, scavenging harmful free radicals and reducing oxidative stress. They help protect cells and tissues from damage caused by oxidative processes. 
• Collagen Synthesis: Vitamin C is essential for synthesis of collagen, a structural protein important for skin, blood vessels, bones, and other connective tissues. 
• Vision Support: beta carotene is converted into vitamin A, which is crucial for vision. Lutein is known for its role in protecting the eyes from oxidative damage, especially in conditions like age-related macular degeneration. 
• Cardiovascular Health: These omega-3 fatty acids have anti-inflammatory properties, reduce triglyceride levels, and support heart health by reducing the risk of cardiovascular events. 
• Neurological Function: Vitamin B12 is essential for nerve function, and deficiency can lead to neurological symptoms. Adequate B12 supports cognitive function and the nervous system. 
• Mineral Homeostasis: Zinc plays a role in enzymatic reactions, DNA synthesis, and wound healing. It contributes to the maintenance of mineral homeostasis in the body. 

Pharmacokinetics: 

Absorption: 

• beta carotene: Absorbed in the small intestine and converted into vitamin A as needed. 
• Vitamin C: Rapidly absorbed in the small intestine through active transport mechanisms. 
• Vitamin E: Absorbed in the small intestine, facilitated by dietary fats. 
• Minerals (Zinc and Selenium): Absorbed in the small intestine through active transport and passive diffusion. 
• Lutein: Absorbed along with dietary fats in the small intestine. 
• EPA and DHA: Absorbed in small intestine, often more efficiently when taken with meals. 
• Vitamin B12: Absorption occurs in the ileum of the small intestine, aided by intrinsic factor. 

Distribution: 

• After absorption, these components are distributed throughout the body via the bloodstream. 
• Vitamins and minerals are transported in the bloodstream and can reach target tissues and organs. 
• Fatty acids like EPA and DHA are incorporated into cell membranes throughout the body, including in the brain and cardiovascular system. 

Metabolism: 

• beta carotene: Converted into active vitamin A (retinol) in the liver and other tissues as needed. 
• Vitamin C and E: These vitamins serve as antioxidants and undergo minimal metabolism. 
• Minerals (Zinc and Selenium): Play essential roles in various metabolic processes. 
• Lutein: Metabolized in the liver. 
• EPA and DHA: Metabolized in the liver and other tissues into bioactive lipid mediators. 
• Vitamin B12: Metabolized in the liver and is involved in various metabolic pathways, including those related to DNA synthesis. 

Excretion: 

• beta carotene: Excreted in the urine, feces, and through sweat. 
• Vitamin C: Excreted in the urine. 
• Vitamin E: Excreted in the urine and feces. 
• Minerals (Zinc and Selenium): Excess amounts are excreted in the urine and feces. 
• Lutein: Excreted in the urine and feces. 
• EPA and DHA: Excreted through the urine, with excess amounts often stored in adipose tissue. 
• Vitamin B12: Excreted in the urine, but much of it is reabsorbed in the ileum. 

Adminstartion

Administration: 

• Dosage and Formulations: Select supplements that provide the desired dosages of each component. The form of supplements (e.g., capsules, tablets, liquid) can vary, so choose one that suits your preferences and needs. 
• Timing: Follow the recommended timing for taking these supplements, which can vary depending on the specific component. Some may be taken with or without food, while others may be more effective when taken with meals. 
• Compliance: Adhere to the recommended dosage and schedule consistently. Avoid excessive intake, as high doses of certain vitamins and minerals can have adverse effects. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: beta carotene, vitamin c, vitamin e, minerals, lutein, eicosapentaenoic acid, docosahexenoic acid and vit b12 

Pronounced: (BAY-tuh kair-uh-teen, VY-tuh-min C, VY-tuh-min E, MIN-uh-rals, LOO-teen, EYE-koh-suh-pen-tuh-EE-noh-ik AS-id, DOH-koh-suh-hek-suh-NOH-ik AS-id-and- VY-tuh-min B12)  

Why do we use beta carotene, vitamin c, vitamin e, minerals, lutein, eicosapentaenoic acid, docosahexenoic acid and vit b12? 

beta carotene, Vitamin C, and Vitamin E act as antioxidants, helping to neutralize the harmful free radicals in body & reduce oxidative stress. This can support overall health and may reduce the risk of chronic diseases. Vitamin C, Zinc, and Selenium play essential roles in immune function. They support the body’s defense against infections and promote a healthy immune system. Vitamin C & Vitamin E are important for skin health. They support collagen production, promote wound healing, and help maintain healthy skin.