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Brand Name :
Canespro
Synonyms :
bifonazole
Class :
Antifungal Agent, Imidazole Derivative, Topical
Brand Name :
Canespro
Synonyms :
bifonazole
Class :
Antifungal Agent, Imidazole Derivative, Topical
Not suggested
Refer to adult dosing
When alprazolam and bifonazole is used together, this leads to reduction in the alprazolam’s metabolism
there is a decrease in absorption of bifonazole, which is seen with decreased serum concentration and also in its reduced efficacy when used in combination with almasilate
the metabolism of digitoxin can be diminished when combined with bifonazole
Actions and Spectrum
bifonazole exhibits antifungal activity thus it is effective against fungal infections caused by susceptible organisms.
bifonazole exerts its antifungal effect by blocking the enzyme lanosterol 14-alpha-demethylase, which is involved in the conversion of lanosterol to ergosterol in the fungal cell membrane.
bifonazole has a broad spectrum of activity against various fungi. It is effective against dermatophytes, yeasts, and molds.
Frequency not defined
Rash, pruritus
Contact and allergic dermatitis
Erythema
Hypersensitivity reactions
Application site pain and peripheral oedema
Skin burning sensation, eczema
Urticaria, dry skin
Skin irritation and maceration
Blister, skin exfoliation
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
bifonazole exerts its antifungal activity by inhibiting the enzyme lanosterol 14-alpha-demethylase. This enzyme is essential for the conversion of lanosterol to ergosterol.
Inhibition of this enzyme disrupts the synthesis of ergosterol, leading to increased permeability and dysfunction of the fungal cell membrane, eventually resulting in cell death.
Pharmacodynamics
bifonazole causes the accumulation of toxic sterol intermediates and reduces the levels of ergosterol.
With the compromised cell membrane, the fungal growth is inhibited, and the affected fungi undergo cellular damage and death.
Pharmacokinetics
Absorption
bifonazole is absorbed through the skin and may penetrate the affected tissues.
Distribution
There is limited information on the distribution of bifonazole within the body.
Metabolism
bifonazole primarily metabolized in the liver.
Elimination and excretion
bifonazole is eliminated from the body through excretion in the urine and feces.
Administration
bifonazole is commonly available in various topical formulations, such as lotions, creams, and powders.
Patient information leaflet
Generic Name: bifonazole
Why do we use bifonazole?
bifonazole is used to treat various fungal infections affecting the skin, nails, and mucous membranes.
bifonazole is effective against dermatophytes, which are fungi that can cause skin infections.
bifonazole can be used to treat yeast infections caused by Candida species.
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