bupleurum

Action and Spectrum

Actions and Spectrum 

Sapogenin A compound found in bupleurum has analgesic properties. The activation of the L-arginine-NO-cGMP-KATP channel and the interaction of the opioid, PPAR, and cannabinoid receptors are what give bupleurum its antinociceptive properties. Polysaccharide bupleurans and saikosaponins both improve the rate of ulcer healing and lessen the consequences of stomach ulcers. It has vasorelaxant properties as well. 

Drug Interaction

Adverse Reaction

Frequency not defined  

Liver damage  

Increased flatulence  

An increase in bowel movements  

Adult respiratory distress syndrome  

Sedation  

Drowsiness  

Black Box Warning

Blackbox warning 

Avoid driving vehicles and operating the machines  

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

Pregnancy 

Lactation 

Multiple sclerosis 

SLE (systemic lupus erythematosus) 

Rheumatoid arthritis 

Caution: 

Bleeding disorders 

Diabetes  

Cancer 

Hepatic impairment 

Pregnancy / Lactation

Pregnancy consideration:  

Safety and efficacy study about the use of bupleurum in pregnancy is not established  

Lactation:  

Safety and efficacy studies about the use of bupleurum in breastfeeding mothers have not been established. 

Pregnancy categories:  

Category A: Studies that were well-controlled and met expectations revealed no risk to the foetus `in either the first or second trimester. 

<b>Category B: There was a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category  

Pharmacology

Pharmacology 

The extracts might be a useful source of pharmacological compounds with potential for anorectic and anti-addictive effects. A saikosaponin-enriched B. falcatum extract has been shown to reduce rats’ self-administration of alcohol and chocolate. 

Pharmacodynamics 

Limited information available 

Pharmacokinetics 

Not much data present on the ADME 

Adminstartion

Administration 

It is administered orally 

Patient Information Leaflet

Patient information leaflet  

Generic Name: bupleurum  

Why do we use bupleurum?  

A natural supplement called bupleurum is used. It offers a wide range of therapeutic benefits. It has protection from liver, fever reducing property, pain reduction and anti-inflammatory properties. It is also recommended for the treatment of diabetes and ulcer repair.