camostat

Action and Spectrum

Actions and Spectrum 

Camostat inhibits the activity of serine proteases, enzymes that play a role in various physiological processes. It targets is the transmembrane protease serine 2 (TMPRSS2).  

Drug Interaction

Adverse Reaction

Frequency not defined  

Itching 

Myositis 

Rhabdomyolysis 

Pancreatic inflammation 

Blood disorder 

Sleep disturbance 

Fatigue 

Gastrointestinal disturbance 

Liver dysfunction 

Headache 

Dizziness 

Muscle pain 

Taste change 

Hypersensitivity 

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• Individuals with a known hypersensitivity or allergy to camostat or any of its components should avoid its use. 

Caution: 

• Caution is advised in individuals with liver impairment.  
• Caution is advised in individuals with bleeding disorders. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

Camostat inhibits the activity of serine proteases, which are enzymes involved in the cleavage of peptide bonds.  

One of its targets is TMPRSS2, a serine protease expressed on the surface of certain cells, including respiratory epithelial cells. 

Pharmacodynamics 

Camostat interferes with the ability of the virus to enter host cells. TMPRSS2 is involved in the activation of viral glycoproteins, including the spike protein of certain coronaviruses. 

Pharmacokinetics 

Limited information available on ADME. 

Adminstartion

Administration 

Camostat is administered orally in the form of tablets. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: camostat 

Why do we use camostat? 

Camostat is used in the treatment of chronic pancreatitis.  

Camostat is also used in the treatment of Post-operative Gastroesophageal reflux disease.