carbomycin

Action and Spectrum

Actions and Spectrum: 

Actions: 

It has been shown that carbomycin is effective in treating infectious disorders brought on by the above-described bacteria. Its ability to prevent the synthesis of proteins required for bacterial cell division accounts for its antibacterial action. The ribosomal peptidyl transferase enzyme, which catalyzes the creation of peptide bonds during protein synthesis, is bound by this medicine. Furthermore, the methionine synthase enzyme, which carbomycin binds to, aids in the conversion of homocysteine to methionine. Carbomycin prevents protein synthesis by interfering with these enzymes’ normal function, which eventually results in bacterial death. 

Spectrum: 

A broad-spectrum, multipurpose antibacterial agent, carbomycin inhibits the growth of a variety of bacteria. It can combat both Gram-negative and Gram-positive bacteria, such as Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, and Streptococcus pneumoniae.

Drug Interaction

Adverse Reaction

Frequency not defined 

Nausea 

Anaphylaxis 

Vomiting 

Elevated liver enzymes 

Myasthenia gravis exacerbation 

QT prolongation 

Abdominal discomfort

Black Box Warning

N/A

Contraindication / Caution

Contraindication/Caution: 

Contraindications 

• Hypersensitivity 

Cautions 

• Renal impairment 
• Hepatic impairment 
• Drug interactions 
• Pregnancy  
• Breastfeeding 

Pregnancy / Lactation

Pregnancy consideration:  

No data is available regarding the administration of the drug during pregnancy. 

Breastfeeding warnings:  

No data is available regarding the excretion of drug in breast milk. 

Pregnancy category: 

Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology: 

Carbomycin is a complex mixture predominantly composed of carbomycin A with a smaller proportion of carbomycin B. Originating from Streptomyces halstedii; this compound serves as an antibiotic. FDA approval has been obtained for carbomycin, commercially known as magna-terramycin (in conjunction with oxytetracycline), specifically for the treatment of chronic bacterial respiratory diseases in chickens. The antibacterial mode of action of Carbomycin entails binding within the significant ribosomal subunit, thereby hindering protein synthesis in bacteria. 

Pharmacodynamics: 

Due to the “accumulation of peptidyl-tRNA in cells at the nonpermissive temperature” of 40˚C, carbomycin hinders protein synthesis in E. coli. It works by encouraging peptidyl-tRNA to separate from the ribosome, which obstructs the nascent peptide chain’s easy escape from the ribosome via the exit tunnel. 

Pharmacokinetics: 

N/A 

Adminstartion

Administration: 

Carbomycin is frequently given orally, either as oral solutions, powders, or capsules. Additionally, it may be administered through injections in certain instances. The frequency of administering carbomycin is determined by the treatment plan prescribed by a veterinarian. Whether carbomycin should be administered with or without food depends on veterinary instructions and the specific product employed in a given situation.

Patient Information Leaflet

Patient information leaflet 

Generic Name: carbomycin 

Pronounced: KAR-boh-MY-sin 

Why do we use carbomycin? 

Carbomycin is frequently utilized to treat respiratory infections in animals, notably among livestock such as poultry, swine, and cattle. It demonstrates effectiveness against bacteria responsible for respiratory issues, including various Mycoplasma species. In addition, carbomycin finds application in the prevention and control of specific infectious diseases in animals, particularly in farming and animal husbandry contexts, where it plays a crucial role in averting the spread of bacterial infections. Historically, like other macrolide antibiotics, carbomycin has been employed as a growth-promoting agent in animal agriculture. However, the use of antibiotics for growth promotion has faced scrutiny due to concerns regarding antibiotic resistance.