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Brand Name :
Mandol
Synonyms :
cefamandole
Class :
cefamandole
Brand Name :
Mandol
Synonyms :
cefamandole
Class :
cefamandole
Dosage Forms & Strengths
Solution
1 g
2 g
Administer dose of 500 mg intramuscularly or intravenously every 6 hours
Administer dose of 500 mg intramuscularly or intravenously every 8 hours
Dosage Forms & Strengths
Solution
1 g
2 g
for infants and Children:
Administer daily dose of 50 to 100 mg/kg intramuscularly or intravenously divided doses every 4 to 8 hours
Refer to adult dosing
It may diminish the excretion when combined with dexamethasone
it may diminish the excretion rate when combined with estradiol valerate resulting in a greater serum level
When cefamandole is used together with piroxicam, this leads to increased risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefamandole, this leads to enhanced risk or seriousness of nephrotoxicity
When cefamandole is used together with proglumetacin, this leads to enhanced risk or seriousness of nephrotoxicity
cefamandole leads to a reduction in the rate of excretion of potassium acetate, which leads to an increased level of serum
cefamandole leads to a reduction in the rate of excretion of potassium perchlorate, which leads to an increased level of serum
cefamandole leads to a reduction in the rate of excretion of nitric oxide, which leads to an increased level of serum
When cefamandole is used together with difenpiramide, this leads to enhanced risk or seriousness of nephrotoxicity
cefamandole may decrease the excretion rate of almasilate, leading to higher serum levels
cefamandole might lead to a reduction in the rate of excretion of telavancin, potentially leading to elevated levels of serum
Actions and Spectrum
cefamandole exerts its antibacterial effects by interfering with the synthesis of bacterial cell walls. Bacterial cell walls are crucial for maintaining the structural integrity of the bacteria.
It works by inhibiting the transpeptidation step of peptidoglycan synthesis, which is necessary for the cross-linking of the cell wall components.
Frequency not defined
Neutropenia
Urticaria
Eosinophilia
Hypersensitivity Anaphylaxis
Rash
Blood Thrombocytopenia
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
cefamandole works by inhibiting bacterial cell wall synthesis. It targets the enzyme transpeptidase which is involved in the cross-linking of peptidoglycan chains in the bacterial cell wall. By inhibiting this process, cefamandole weakens the cell wall, leading to osmotic instability and eventual cell lysis.
Pharmacodynamics
cefamandole’s bactericidal activity is time-dependent, which means that its effectiveness is correlated with the amount of time the drug concentration remains above a certain threshold.
Pharmacokinetics
Absorption
Intravenous administration leads to rapid and bioavailability as the drug directly enters the bloodstream.
Distribution
cefamandole has a broad distribution in the body.
Metabolism
cefamandole undergoes minimal metabolism in the liver.
Elimination and excretion
Renal excretion is the primary route by which cefamandole is eliminated from the body.
Administration
cefamandole is typically administered intravenously (IV) or intramuscularly (IM).
Patient information leaflet
Generic Name: cefamandole
Why do we use cefamandole?
cefamandole is an antibiotic medication that has been used to treat various bacterial infections.
cefamandole has been used to treat uncomplicated urinary tract infections caused by susceptible bacteria.
cefamandole has been used to treat respiratory tract infections such as pneumonia, bronchitis, and bacterial exacerbations of chronic obstructive pulmonary disease (COPD).
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