Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
N/A
Synonyms :
Cefatrizine, cefatrizina, cefatrizinum
Class :
Antibacterial antibiotics/ EF2K inhibitors
Brand Name :
N/A
Synonyms :
Cefatrizine, cefatrizina, cefatrizinum
Class :
Antibacterial antibiotics/ EF2K inhibitors
Dosage Forms & Strengths
Capsules
Adult dosing
Urinary tract infections (Off-label)
Invivo studies suggest 1mg/kg orally four times a day 3 days
Infections of the kidney (off-label)
Invivo studies suggests: 0.2mg/kg orally four times a day 3 days
Orally 
In vivo studies suggest 1mg/kg orally four times a day 3 days
Orally 
In vivo studies suggest 1mg/kg orally four times a day 3 days
Orally 
In vivo studies suggest 1mg/kg orally four times a day 3 days
Orally 
In vivo studies suggest 1mg/kg orally four times a day 3 days
the excretion rate may be decreased
the therapeutic activity may be reduced
Actions and spectrum:
Cefatrizine inhibits the cell wall synthesis by inactivating penicillin binding proteins which alters the maintenance of structural integrity that leads to the death of bacteria.
Adverse reactions
Black box warning
Do not drive or operate heavy machinery.
Contraindications/Caution
Hypersensitivity
Pregnancy & breastfeeding:
Pregnancy consideration:
USFDA pregnancy category: B
Breastfeeding warnings:
The excretion of drug into human milk is known
Pregnancy categories:
Pharmacology:
Cefatrizine showed significant efficacy against gram-positive cocci, Proteus mirabilis, Klebsiella pneumoniae, Escherichia coli, and Salmonella at concentrations below 1 ÎĽg/ml.
It also inhibits most β-lactamases but is ineffective against Serratia, Enterobacter, and indole-positive Proteus.
It showed superior activity against E. coli, Enterobacter, Klebsiella, Citrobacter, and Shigella compared to cephalexin and cephalothin..
It also inhibits eEF2K.
Pharmacodynamics:
Cefatrizine has an anti-proliferative effect by acting as an inhibitor of eEF2K.
This drug induces ER (endoplasmic reticulum) stress in cells of human breast cancer, leading to cell death.
Pharmacokinetics:
Absorption: It is absorbed rapidly in oral administration.
The process of absorption varies in a dose-dependent manner.
Distribution: It is well distributed in the body tissues.
Elimination: Oral cephalosporins usually undergo renal elimination.
Most of the drug is eliminated in unchanged form through urine.
Half-life: 3 hours
Administration:
Cefatrizine is administered orally in the form of capsules.
This may be given with or without food.
Patient information leaflet
Generic Name: cefatrizine
Pronounced: sae-pha-tri-jeen
Why do we use cefatrizine?
Cefatrizine is an oral cephalosporin has shown efficacy in treating bacterial infections in both adults and pediatrics with mild gastrointestinal disturbances as the primary adverse reaction.
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