How Far Is Too Far? The Ethics of Mini Brain Research
December 11, 2025
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Brand Name :
Monocid
Synonyms :
cefonicid
Class :
Cephalosporin
Brand Name :
Monocid
Synonyms :
cefonicid
Class :
Cephalosporin
Dosage Forms & Strengths
Solution
1 g
Administer dose of 0.5 to 2 g daily intramuscularly or intravenously in 1 or 2 daily doses
Not suggested
Refer to adult dosing
may diminish the rate of excretion leading to a higher serum level
may diminish the rate of excretion leading to a higher serum level
may diminish the rate of excretion leading to a higher serum level
may diminish the rate of excretion leading to a higher serum level
may diminish the rate of excretion leading to a higher serum level
may diminish the rate of excretion leading to a higher serum level
may diminish the rate of excretion leading to a higher serum level
may diminish the rate of excretion leading to a higher serum level
may diminish the rate of excretion leading to a higher serum level
may diminish the rate of excretion leading to a higher serum level
may diminish the rate of excretion which results in higher serum level
may diminish the rate of excretion which results in higher serum level
may diminish the rate of excretion which results in higher serum level
may diminish the rate of excretion which results in higher serum level
may diminish the rate of excretion which results in higher serum level
cephalosporins increase the effect of anticoagulation of vitamin K antagonists
cephalosporins increase the effect of anticoagulation of vitamin K antagonists
cephalosporins increase the effect of anticoagulation of vitamin K antagonists
cephalosporins increase the effect of anticoagulation of vitamin K antagonists
cephalosporins increase the effect of anticoagulation of vitamin K antagonists
they increase the effect of nephrotoxicity of aminoglycosides
neomycin/polymyxin B/bacitracin topical
they increase the effect of nephrotoxicity of aminoglycosides
they increase the effect of nephrotoxicity of aminoglycosides
they increase the effect of nephrotoxicity of aminoglycosides
they increase the effect of nephrotoxicity of aminoglycosides
it may diminish the excretion rate when combined with estradiol valerate resulting in a greater serum level
it may enhance the risk of nephrotoxicity when combined with phenylbutazone
cefonicid has the potential to reduce the rate of excretion of idebenone, leading to an elevation in levels of serum
When cefonicid is used together with piroxicam, this leads to increased risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefonicid, this leads to enhanced risk or seriousness of nephrotoxicity
When cefonicid is used together with proglumetacin, this leads to enhanced risk or seriousness of nephrotoxicity
When cefonicid is used together with benoxaprofen, this leads to enhanced risk or seriousness of nephrotoxicity
cefonicid leads to a reduction in the rate of excretion of eucalyptus oil which leads to increased level of serum
cefonicid leads to a reduction in the rate of excretion of pentaerythritol tetranitrate, which leads to an increased level of serum
cefonicid leads to a reduction in the rate of excretion of potassium perchlorate, which leads to an increased level of serum
cefonicid leads to a reduction in the rate of excretion of nitric oxide, which leads to an increased level of serum
When cefonicid is used together with difenpiramide, this leads to enhanced risk or seriousness of nephrotoxicity
may diminish the rate of excretion which results in higher serum level
may diminish the rate of excretion which results in higher serum level
may diminish the rate of excretion which results in higher serum level
may diminish the rate of excretion which results in higher serum level
may diminish the rate of excretion which results in higher serum level
cefonicid may decrease the excretion rate of almasilate, leading to higher serum levels
cefonicid might lead to a reduction in the rate of excretion of telavancin, potentially leading to elevated levels of serum
Actions and Spectrum
cefonicid works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins present on the bacterial cell wall, interfering with the cross-linking of peptidoglycan strands. Its spectrum includes both Gram-positive and Gram-negative bacteria.
Frequency not defined
Bleeding diatheses
Leucopenia
Coagulopathies
Eosinophilia
Thrombocytosis
Neutropenia
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
cefonicid primarily targets growing and dividing bacterial cells.
The disruption weakens the integrity of the bacterial cell wall, leading to cell lysis and death.
Pharmacodynamics
cefonicid exhibits time-dependent bactericidal activity thus its effectiveness is closely related to the time that the drug concentration remains above the minimum inhibitory concentration (MIC) of the targeted bacteria.
Pharmacokinetics
Absorption
cefonicid is administered intravenously so it allows for rapid absorption of the drug directly into the bloodstream.
Distribution
cefonicid is distributed throughout various body tissues and fluids.
Metabolism
cefonicid undergoes minimal metabolic transformations in the liver.
Elimination and excretion
The primary route of excretion for cefonicid is via the kidneys.
Administration
cefonicid is commonly administered intravenously (IV) and intramuscularly (IM).
Patient information leaflet
Generic Name: cefonicid
Why do we use cefonicid?
cefonicid can be used to treat infections of the skin, including cellulitis, wound infections, and abscesses caused by susceptible bacteria. cefonicid also be used to treat respiratory infections like pneumonia and bronchitis. cefonicid can be effective against urinary tract infections (UTIs) caused by susceptible bacteria.
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