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December 18, 2025
Brand Name :
Chlo Tuss
Synonyms :
chlophedianol/dexbrompheniramine/pseudoephedrine
Class :
Alkylamine Derivative, Antitussive, Decongestant, Histamine H1 Antagonist, First Generation
Dosage Forms & Strengths
Liquid
12.5mg/1mg/30mg/5 ml
(chlophedianol/dexbrompheniramine/ pseudoephedrine)/5ml
Allergy Symptoms And Common Cold
Take dose of 10 ml orally every 6 hours
Maximum dose more than 40 ml in a day
Dosage Modifications
Renal Impairment
No dose modification suggested
Hepatic Impairment
No dose modification suggested
Dosage Forms & Strengths
Liquid
12.5 mg/1 mg/30 mg per 5 ml
(chlophedianol/dexbrompheniramine/ pseudoephedrine)/5ml
Allergy Symptoms And Common Cold
For 6 to <12 years:
Take dose of 5 ml orally every 6 hours as required
Maximum daily dose not more than 20 ml in a day
For ≥12 years:
Take dose of 10 ml orally every 6 hours as required
Maximum daily dose not more than 40 ml in a day
Refer to adult dosing
Actions and Spectrum
chlophedianol is a cough suppressant that works by acting on the cough centre in the brain to reduce coughing.
dexbrompheniramine is an antihistamine that blocks the effects of histamine, a substance released during allergic reactions.
pseudoephedrine is a decongestant that works by narrowing the blood vessels in the nasal passages.
chlophedianol helps suppress coughing, dexbrompheniramine alleviates allergy symptoms, and pseudoephedrine reduces nasal congestion.
Frequency not defined
Excitability
Insomnia
Dizziness
Nervousness
Drowsiness
Black Box Warning
None
Contraindication/Caution:
Contraindication:
pseudoephedrine should not be used in individuals who have taken or are currently taking monoamine oxidase inhibitors (MAOIs) within the past 14 days.
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
chlophedianol works by reducing the sensitivity of the cough reflex, thereby reducing coughing.
dexbrompheniramine exert actions by selectively antagonizing the H1 histamine receptors, thereby reducing the symptoms of allergies such as sneezing, itching and runny nose.
pseudoephedrine is a sympathomimetic amine which works by constricting the blood vessels in the nasal passages, which reduces swelling and congestion.
Pharmacodynamics
Limited information available
Pharmacokinetics
Absorption
chlophedianol is absorbed orally with peak plasma concentrations reached within 1 to 2 hours.
dexbrompheniramine is also absorbed after oral administration, with peak plasma concentrations occurring within 2 to 6 hours.
pseudoephedrine is absorbed after oral administration, with peak plasma concentrations occurring within 1 to 2 hours.
Distribution
chlophedianol/dexbrompheniramine/ pseudoephedrine all are widely distributed throughout the body, including the central nervous system (CNS).
Metabolism
chlophedianol/dexbrompheniramine/ pseudoephedrine all undergoes extensive hepatic metabolism, primarily through oxidation and conjugation processes.
Elimination and excretion
The metabolites of chlophedianol/ dexbrompheniramine/pseudoephedrine are mainly excreted in the urine.
Administration
chlophedianol/dexbrompheniramine/ pseudoephedrine is available in the form of oral tablets or capsules.
Patient information leaflet
Generic Name: chlophedianol/ dexbrompheniramine/ pseudoephedrine
Why do we use chlophedianol/ dexbrompheniramine/ pseudoephedrine?
chlophedianol/dexbrompheniramine/ pseudoephedrine is a combination drug used for the relief of symptoms associated with respiratory conditions, such as the common cold, allergies and hay fever. chlophedianol, acts as a cough suppressant and helps alleviate coughing associated with respiratory tract irritations.
dexbrompheniramine, an antihistamine provides relief from symptoms of allergic rhinitis, including sneezing, itching and runny nose. pseudoephedrine, a decongestant component, helps reduce nasal congestion by constricting blood vessels in the nasal passage.