chlophedianol/dexbrompheniramine/pseudoephedrine

Action and Spectrum

Actions and Spectrum 

chlophedianol is a cough suppressant that works by acting on the cough centre in the brain to reduce coughing.  

dexbrompheniramine is an antihistamine that blocks the effects of histamine, a substance released during allergic reactions.  

pseudoephedrine is a decongestant that works by narrowing the blood vessels in the nasal passages.  

chlophedianol helps suppress coughing, dexbrompheniramine alleviates allergy symptoms, and pseudoephedrine reduces nasal congestion. 

Drug Interaction

Adverse Reaction

Frequency not defined  

Excitability 

Insomnia 

Dizziness 

Nervousness 

Drowsiness  

Black Box Warning

Black Box Warning 

None

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• The drug should not be used in individuals who have a known hypersensitivity or allergy to any of its active ingredients or any related compounds. 
• chlophedianol/dexbrompheniramine/ 

pseudoephedrine should not be used in individuals who have taken or are currently taking monoamine oxidase inhibitors (MAOIs) within the past 14 days. 

Caution: 

• chlophedianol/dexbrompheniramine/pseudoephedrine should be used with caution in individuals with thyroid disorders.  
• The medication should be used with caution in individuals with cardiovascular conditions such as high blood pressure, coronary artery disease. 
• Use with caution in patients with prostatic hyperplasia and or GU obstruction. 
• The medication should be used cautiously in individuals with glaucoma. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

chlophedianol works by reducing the sensitivity of the cough reflex, thereby reducing coughing. 

dexbrompheniramine exert actions by selectively antagonizing the H1 histamine receptors, thereby reducing the symptoms of allergies such as sneezing, itching and runny nose. 

pseudoephedrine is a sympathomimetic amine which works by constricting the blood vessels in the nasal passages, which reduces swelling and congestion. 

Pharmacodynamics 

Limited information available  

Pharmacokinetics 

Absorption   

chlophedianol is absorbed orally with peak plasma concentrations reached within 1 to 2 hours. 

dexbrompheniramine is also absorbed after oral administration, with peak plasma concentrations occurring within 2 to 6 hours. 

pseudoephedrine is absorbed after oral administration, with peak plasma concentrations occurring within 1 to 2 hours. 

Distribution 

chlophedianol/dexbrompheniramine/ pseudoephedrine all are widely distributed throughout the body, including the central nervous system (CNS). 

Metabolism 

chlophedianol/dexbrompheniramine/ pseudoephedrine all undergoes extensive hepatic metabolism, primarily through oxidation and conjugation processes. 

Elimination and excretion 

The metabolites of chlophedianol/ dexbrompheniramine/pseudoephedrine are mainly excreted in the urine.

Adminstartion

Administration 

chlophedianol/dexbrompheniramine/ pseudoephedrine is available in the form of oral tablets or capsules.

Patient Information Leaflet

Patient information leaflet 

Generic Name: chlophedianol/ dexbrompheniramine/ pseudoephedrine 

Why do we use chlophedianol/ dexbrompheniramine/ pseudoephedrine? 

chlophedianol/dexbrompheniramine/ pseudoephedrine is a combination drug used for the relief of symptoms associated with respiratory conditions, such as the common cold, allergies and hay fever. chlophedianol, acts as a cough suppressant and helps alleviate coughing associated with respiratory tract irritations.  

dexbrompheniramine, an antihistamine provides relief from symptoms of allergic rhinitis, including sneezing, itching and runny nose. pseudoephedrine, a decongestant component, helps reduce nasal congestion by constricting blood vessels in the nasal passage.