chlorcyclizine

Action and Spectrum

Actions and Spectrum: 

Action:
As an antihistamine, chlorcyclizine works by preventing the effects of histamine, a chemical generated during allergic reactions, which helps with symptoms of allergies such as itching, sneezing, and runny nose. 

Drug Interaction

Adverse Reaction

Frequency not defined   

Swelling of the face, lips, or tongue  

Trouble passing urine   

Skin rash  

Itching or hives  

Vision change 

Black Box Warning

Black Box Warning  

None  

Contraindication / Caution

Contraindication/Caution:  

Contraindication:  

Hypersenstivity 

Caution:  

 Liver or kidney disease 

Narrow-angle glaucoma 

Pregnancy / Lactation

Pregnancy consideration:  

Pregnancy category: N/A  

Lactation: Excretion into human milk is unknown   

Pregnancy Categories:          

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.  

Category B: There was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.   

Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.  

Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.  

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology   

Antihistamines like chlorcyclizine also have sedative and anticholinergic effects. 

Pharmacodynamics  

By inhibiting histamine H1 receptors, chlorcyclizine stops allergic symptoms such as sneezing, runny nose and itching. 

Pharmacokinetics  

Absorption    

Chlorcyclizine is absorbed in the GI tract.  

Distribution  

The distribution occurs throughout the body.  

Metabolism  

Chlorcyclizine undergoes metabolism primarily in the liver.  

Excretion and Elimination  

The excretion occurs through urine. 

Adminstartion

Administration  

The route of administration is oral. 

Patient Information Leaflet

Patient information leaflet  

Generic Name: chlorcyclizine  

Why do we use chlorcyclizine?  

The drug is used for treating rhinitis symptoms nasal congestion, runny nose, itching, sneezing & symptoms of pollen allergy.