chromic chloride

Action and Spectrum

Actions and spectrum: 

• Chemical Properties: chromic chloride is a chemical compound with the formula CrCl₃. It exists in several hydrate forms, and its chemical properties include its role as a source of chromium ions in various chemical reactions. 
• Catalyst: chromic chloride is commonly used as a catalyst in organic synthesis, especially in the activation of certain reagents. It can facilitate the formation of carbon-carbon bonds and other organic transformations. 
• Chromium Supplement: In certain formulations, chromic chloride has been explored as a potential source of chromium for dietary supplementation. Chromium is an essential element involved in various metabolic processes. 
• Dyes and Pigments: Chromium(III) chloride is utilized in the production of various dyes and pigments. Its compounds contribute to the coloration of materials in the fields of textiles and coatings. 
• Electroplating: chromic chloride is used in the electroplating industry for the deposition of chromium on various surfaces. Chromium-plating provides corrosion resistance and an attractive finish. 

The spectrum of chromic chloride’s applications demonstrates its versatility in different fields, ranging from catalysis in organic chemistry to industrial processes like electroplating and the production of dyes. The specific action and utility depend on the intended use in a particular context. As with any chemical compound, it is important to handle chromic chloride with care and adhere to safety guidelines. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Gastro-intestinal symptoms 

Arrhythmias 

Decreased blood pressure 

Tingling sensation 

Sense of oppression 

Hypertension 

Nausea 

Flushing 

Bradycardia 

Irritation 

Hot flushes 

Peripheral vasodilatation 

hypercalcaemia 

Drowsiness 

Sweating 

Black Box Warning

Black Box Warning: 

chromic chloride is not associated with a specific black box warning. 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• Toxicity of Hexavalent Chromium: Chromium can exist in different oxidation states, with hexavalent chromium (Cr (VI)) being a more toxic form. Exposure to Cr (VI) compounds, which may be generated during certain industrial processes, can pose health risks, and is associated with respiratory and skin irritation. 
• Occupational Safety: Workers handling chromic chloride or involved in processes using chromium compounds should adhere to occupational safety guidelines and use appropriate protective measures, such as eye protection, gloves, and respiratory protection. 
• Inhalation Exposure: Inhalation of dust or fumes containing chromium compounds should be minimized. Adequate ventilation and respiratory protection may be necessary in certain industrial settings. 
• Environmental Impact: chromic chloride and other chromium compounds can have environmental implications. Disposal should be carried out following environmental regulations. 

Caution: 

• Skin Contact: chromic chloride solutions can cause skin irritation. Direct skin contact should be avoided, and appropriate personal protective equipment, such as gloves and long sleeves, should be worn when handling solutions or materials containing chromic chloride. 
• Eye Contact: Contact with chromic chloride can cause eye irritation. Eye protection, such as safety goggles or a face shield, should be worn when there is a risk of splashing or exposure. 
• Inhalation: Inhalation of dust or fumes containing chromium compounds should be minimized. Adequate ventilation and, if necessary, respiratory protection should be used in industrial settings where chromic chloride is handled. 
• Protective Clothing: Workers handling chromic chloride should wear appropriate protective clothing to prevent skin exposure. This may include chemical-resistant gloves, long sleeves, and long pants.

Comorbidities: 

• Respiratory Issues: Prolonged exposure to airborne chromium compounds, especially hexavalent chromium (Cr (VI)), can lead to respiratory issues such as irritation of the respiratory tract, coughing, and difficulty breathing. 
• Skin Irritation: Direct skin contact with chromic chloride solutions may cause skin irritation, including redness and itching. 
• Eye Irritation: Exposure to chromic chloride can lead to eye irritation, causing redness, tearing, and discomfort. 
• Allergies and Sensitization: Some individuals may develop allergies or sensitization to chromium compounds after repeated exposure, leading to dermatitis or other allergic reactions. 
• Occupational Asthma: In certain occupational settings where there is exposure to chromium compounds, there may be an increased risk of developing occupational asthma. 

Pregnancy / Lactation

Pregnancy consideration: pregnancy category: not assigned 

Lactation: excreted into human milk: unknown  

Pregnancy category: 

• Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 
• Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 
• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   
• Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 
• Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology: 

chromic chloride (chromium (III) chloride) is not typically characterized by pharmacological properties in the traditional sense, as it is not a medication designed for therapeutic use. Instead, chromic chloride is a chemical compound with diverse applications in industrial and chemical processes.

Its pharmacology, if broadly considered, involves its role as a source of trivalent ions in various reactions. Trivalent chromium is an essential element for human nutrition, playing a role in glucose metabolism. However, the use of chromic chloride in industrial settings, such as catalysis, electroplating, and the production of dyes, focuses on its chemical and physical properties rather than pharmacological actions.

It is important to note that the potential health effects associated with chromium compounds, including chromic chloride, are more pertinent to occupational and environmental exposure rather than therapeutic applications. Safety measures and precautions are crucial when handling this compound to minimize potential health risks.  

Pharmacodynamics: 

chromic chloride (chromium (III) chloride) does not exhibit traditional pharmacodynamic properties associated with medications because it is not a therapeutic agent. chromic chloride, its primary use is in various industrial processes rather than for medical purposes. 

Chromium, in its trivalent form found in chromic chloride, is an essential trace element for human nutrition and is involved in glucose metabolism. However, the pharmacodynamics of trivalent chromium in the body, as opposed to its industrial applications, is more related to its nutritional role than any specific drug action. 

It is crucial to recognize that the potential health effects and toxicity associated with chromium compounds, including chromic chloride, are more relevant in occupational and environmental contexts where exposure may occur. In these settings, the emphasis is on understanding the chemical and toxicological properties of chromium rather than its pharmacodynamic effects in a therapeutic sense.

Occupational safety measures and regulatory guidelines are established to minimize exposure and protect individuals working with or around chromium compounds.  

Pharmacokinetics: 

• Absorption: chromic chloride is not intended for oral consumption, and absorption through the gastrointestinal tract is not a primary concern. It is typically encountered in occupational or environmental settings, where exposure may occur through inhalation or skin contact. 
• Distribution: Trivalent chromium, the form found in chromic chloride, is believed to be poorly absorbed by the body, and any absorbed chromium is distributed throughout tissues. However, the majority of ingested chromium is excreted in the feces. 
• Metabolism: Trivalent chromium is considered to have low toxicity, and metabolic transformation is not a significant aspect in the context of chromic chloride exposure. Chromium is involved in normal metabolic processes, particularly in glucose metabolism. 
• Excretion: The primary route of excretion for chromium, including that from chromic chloride exposure, is through the urine. A portion of ingested chromium is also excreted in the feces. 

Adminstartion

Administration: 

• Safety Precautions: Individuals handling chromic chloride should wear appropriate personal protective equipment (PPE), including gloves, safety goggles or a face shield, and suitable clothing to prevent skin contact and eye exposure. 
• Ventilation: Work areas where chromic chloride is used should be well-ventilated to minimize inhalation exposure. Adequate ventilation systems or fume hoods may be employed. 
• Avoiding Ingestion: chromic chloride is not intended for ingestion. Measures should be taken to prevent accidental ingestion, and eating, drinking, or smoking in areas where chromic chloride is present should be prohibited. 
• Storage: chromic chloride should be stored in accordance with safety guidelines, away from incompatible substances, and in a cool, dry place. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: chromic chloride 

Pronounced: (kroh-mik klor-ahyd)  

Why do we use chromic chloride? 

chromic chloride is used as a catalyst in various chemical reactions, particularly in organic synthesis. It can facilitate the activation of certain reagents and promote specific chemical transformations. chromic chloride is employed in the production of textile dyes and pigments. It contributes to the coloration of materials in the textile and leather industries.

In the electroplating industry, chromic chloride is used in the chromium plating process to create a protective and decorative coating on metal surfaces. chromic chloride is used in wood preservation treatments. It can help protect wood from decay and deterioration, extending its lifespan in outdoor or harsh environments.

In early photographic processes, chromic chloride was used in the preparation of light-sensitive emulsions for black and white photography. It is utilized in metal finishing processes to improve the corrosion resistance and aesthetic appearance of metal products.