clocortolone

Action and Spectrum

Actions and Spectrum: 

Actions 

clocortolone is a topical corticosteroid medication that is used for the treatment of various inflammatory skin conditions. It possesses anti-inflammatory, anti-pruritic (anti-itch), and vasoconstrictive properties.  

It inhibits the production of inflammatory mediators, such as prostaglandins and leukotrienes, and suppressing the immune cells’ activity in the inflammatory response. This action helps to reduce redness, swelling, and itching associated with inflammatory skin conditions. 

Spectrum 

clocortolone is primarily indicated for treating various inflammatory and pruritic (itchy) skin conditions, including dermatitis, psoriasis, allergic reactions, and eczematous skin conditions.

Drug Interaction

Adverse Reaction

Frequency not defined 

Skin atrophy 

Striae 

Papular rash 

Dryness 

Itching 

Erythema 

Irritation 

Acneiform lesions 

Pigmentation changes 

Hypertrichosis 

Maceration of skin 

Black Box Warning

Black Box Warning: 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication 

• Hypersensitivity 
• Viral skin lesions 

Caution 

• Bacterial infections 
• Fungal infections 
• Skin atrophy 
• Systemic absorption 
• Long-term use 
• Pregnancy  
• Breastfeeding 

Pregnancy / Lactation

Pregnancy consideration:  

Pregnancy category: C 

Breastfeeding warnings:  

The excretion of the drug in breastmilk is unknown; hence, use it cautiously during lactation. 

Pregnancy category: 

Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology:  

clocortolone inhibits the synthesis and release of inflammatory mediators, such as prostaglandins, leukotrienes, and cytokines. It also reduces the migration of inflammatory cells to the site of inflammation. These actions help to alleviate inflammation, swelling, and discomfort in the affected skin areas.  

Pharmacodynamics: 

clocortolone has vasoconstrictive properties, which causes the narrowing of blood vessels in the skin. This vasoconstriction helps to reduce redness and relieve symptoms associated with skin inflammation.  

Topical corticosteroids like clocortolone can suppress the immune response locally in the skin. They inhibit the function of immune cells, such as mast cells and T-lymphocytes, thereby reducing the release of inflammatory substances and immune reactions involved in various skin disorders. 

Pharmacokinetics: 

Absorption 

When applied topically, clocortolone is absorbed through the skin. The extent of absorption depends on factors such as formulation, concentration, skin integrity, and the use of occlusive dressings. Topical corticosteroids are typically designed to have low systemic absorption, leading to primarily local effects.  

Distribution 

Once absorbed, clocortolone may be distributed into the skin layers and possibly into systemic circulation in minimal amounts. However, it is expected that most clocortolone remains localized in the skin tissues at the application site.  

Metabolism 

The metabolism of clocortolone is not extensively described in the available literature. However, like other corticosteroids, it is expected to undergo metabolism in the liver and other tissues, primarily via enzymatic pathways. The specific metabolites and metabolic pathways of clocortolone need to be well documented.  

Elimination and Excretion 

The elimination of clocortolone and its metabolites primarily occurs through excretion. Metabolized components may be eliminated via urine and feces. The exact elimination half-life and clearance of clocortolone need to be better established. 

Adminstartion

Administration: 

Before applying clocortolone, clean the affected area with light soap and water and gently pat it dry. Ensuring the area is clean and free from debris or other topical products is essential. 

Apply a sufficient amount of clocortolone cream, ointment, or lotion to the affected area. Use enough to cover the entire area with a thin and even layer. Avoid excessive amounts as they may increase the risk of systemic absorption and any side effects. 

After applying clocortolone, gently massage or rub it into the skin until it is absorbed. This helps to ensure even distribution and optimal absorption of the medication. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: clocortolone 

Pronounced as: kloe-KOR-toe-lone 

Why do we use clocortolone? 

clocortolone effectively manages inflammatory skin conditions characterized by redness, itching, swelling, and irritation. It can be used for conditions such as eczema (atopic dermatitis), psoriasis, contact dermatitis, seborrheic dermatitis, and allergic reactions on the skin. clocortolone helps reduce inflammation, alleviate itching, and relieve discomfort associated with these conditions.