Best EHR Systems Every Mental Health Provider Should Consider in 2026
April 3, 2026
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Brand Name :
Triacin C, Polyhist NC, Triafed & Codeine Allerfrin with Codeine
Synonyms :
codeine/triprolidine/pseudoephedrine
Class :
Antitussives, Narcotic combos
Brand Name :
Triacin C, Polyhist NC, Triafed & Codeine Allerfrin with Codeine
Synonyms :
codeine/triprolidine/pseudoephedrine
Class :
Antitussives, Narcotic combos
Dosage forms and strengths
pseudoephedrine/codeine/triprolidine
oral syrup-(Schedule V)
30mg/10mg/2mg/5mL
Tablet- (Schedule V)
60mg /20mg/4mg
Syrup- Take 10 mL orally every 4-6 hours, containing 20 mg/ 4 mg/60 mg
Do not exceed 40 mL within a 24-hour period
Tablet- Take 1 tablet orally every 6 hours
Dosage forms and strengths
pseudoephedrine/codeine/triprolidine
oral syrup-(Schedule V)
30mg /10mg/2mg/5mL
Tablet- (Schedule V)
30mg /20mg/4mg/5mL
Age (6-12) years
Administer 5 ml orally every 4 to 6 hours, not exceeding a total of 20 ml within a 24-hour period
Age (>12) years
Syrup-Administer 10 mL orally every 4 to 6 hours, with a daily dose of 40 mL within a 24-hour duration
Tablet-Take one tablet orally every 6 hours
Refer adult dosing
Actions and Spectrum
Action: opioid analgesic and antitussive (cough suppressant).
Spectrum: mild to moderate pain and as a cough suppressant.
Action: antihistamines
Spectrum: allergy symptoms, including allergic rhinitis (hay fever) and other respiratory allergies.
pseudoephedrine:
Action: sympathomimetic amine and decongestant
Spectrum: nasal decongestant
Frequency defined
>10%
Drowsiness
Constipation
1-10%
histamine release
LFT’s increased
blurred vision ,Burning at injection site
tachycardia, Bradycardia, hypotension
Ureteral spasm, urination decreased
false feeling of wellbeing ,Confusion, dizziness
malaise, headache, lightheadedness
Rash, urticaria
vomiting, Anorexia, nausea, xerostomia
weakness, paradoxical CNS stimulation, restlessness
Dyspnea
Frequency not defined
codeine (serious)
Respiratory depression
Anaphylactoid reaction (rare)
Seizure, With excessive doses
Hypotension, With IV use
pseudoephedrine
Vomiting
Insomnia
Nausea
CNS (tremor, restlessness, etc)
triprolidine
Drowsiness
Anti-cholinergic
Dizziness
Black Box Warning:
None
Contraindication/Caution:
pseudoephedrine
triprolidine
codeine
diarrhea associated w/ toxins
Cautions:
triprolidine
pseudoephedrine
codeine
Pregnancy warnings:
Pregnancy category: C
Lactation: Excreted into human milk is known
Pregnancy Categories:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
codeine is an opioid analgesic, triprolidine is an antihistamine, and pseudoephedrine is a sympathomimetic amine. These three medications are commonly combined in specific formulations for treating of cough, cold, and allergy symptoms.
Pharmacodynamics:
pseudoephedrine: Alpha-adrenergic agonist
codeine: mu receptor agonist ,Narcotic agonist analgesic with antitussive activity
triprolidine: proplamine-derivative, First generation antihistamine
Pharmacokinetics:
Absorption
codeine, when taken orally, is quickly absorbed from the gastrointestinal tract and reaches its highest levels in the bloodstream within a period of 1 to 2 hours
Similarly, triprolidine, when administered orally, is also efficiently absorbed and achieves peak plasma concentrations within the same time of 1 to 2 hours.
pseudoephedrine is rapidly absorbed following oral intake, with peak plasma concentrations being attained within 1 to 2 hours.
Distribution
codeine is extensively distributed throughout the body, including the central nervous system, liver, and other tissues.
triprolidine has a moderate distribution throughout the body, including the central nervous system.
pseudoephedrine is distributed widely in the body, including the central nervous system.
Metabolism
codeine is primarily metabolized in the liver by the enzyme CYP2D6 into its active metabolite, morphine, which provides its analgesic effects.
triprolidine undergoes hepatic metabolism via various cytochrome P450 enzymes, mainly CYP2D6 and CYP3A4.
pseudoephedrine undergoes hepatic metabolism, primarily via the enzyme CYP2D6, to form norpseudoephedrine (also known as cathine)
Excretion and Elimination
The metabolites of codeine, including morphine, are primarily excreted in the urine.
triprolidine and its metabolites are eliminated predominantly through urine and feces.
pseudoephedrine and its metabolites are primarily excreted in the urine.
Administration:
Oral Administration
In form of Tablet and syrups in prescribed dosage
Patient information leaflet
Generic Name: codeine/triprolidine/pseudoephedrine
Why do we use codeine/triprolidine/pseudoephedrine?
codeine:
Pain relief: codeine is an opioid analgesic commonly used to alleviate mild to moderate pain. It is often prescribed for conditions such as dental pain, post-operative pain and injuries.
Cough suppression: codeine can be an effective cough suppressant and is frequently included in cough syrups to help relieve persistent coughing.
triprolidine:
Allergic rhinitis: triprolidine is a commonly prescribed antihistamine that helps to alleviate symptoms linked to allergic rhinitis (commonly known as hay fever), including sneezing, itching, and a runny nose.
Itchy skin conditions: triprolidine can also relieve itching caused by certain skin conditions, such as hives or eczema.
pseudoephedrine:
Nasal congestion: pseudoephedrine is a commonly used decongestant that aids in alleviating nasal congestion resulting from the common cold, sinusitis, or allergies. Its mechanism of action involves the constriction of blood vessels within the nasal passages, effectively diminishing swelling and congestion.
Sinus pressure: pseudoephedrine can also help alleviate sinus pressure associated with sinusitis or congestion.
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