Microplastics and Misinformation: What Science Really Says
November 12, 2025
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Brand Name :
Histex
Synonyms :
triprolidine
Class :
Antihistamines
Brand Name :
Histex
Synonyms :
triprolidine
Class :
Antihistamines
Dosing forms and strengths
oral liquid
0.5mg/mL
0.625mg/mL
Histex:The recommended dose is 2.5 mg equivalent to 5 ml orally every four times a day
M-Hist PD or Vanahist PD:The recommended dose is 2.5 mg equivalent to 5 ml orally every four times a day
Dosing forms and strengths
oral liquid
0.5mg/mL
0.625mg/mL
Histex
For age years 6 -<12
The recommended dose is 1.25 mg equivalent to 2.5 ml orally four times a day or as needed
For age years ≥12
The recommended dose is 2.5 mg equivalent to 5 ml orally four times a day
M-Hist PD or Vanahist PD
For age Years 6 -<12 years
The recommended dose is 1.25 mg equivalent to 2 ml orally four times a day or as needed
For age years ≥12
The recommended dose is 2.5 mg equivalent to 4 ml orally four times a day
Refer adult dosing
it may enhance the risk of QTc prolongation when combined with amifampridine
there is an increased risk or severity of CNS depression when triprolidine is combined with tubocurarine
nabilone and triprolidine, when used simultaneously, both increase the sedation
when combined, it may increase sedation
when combined, it may increase sedation
brimonidine and triprolidine lead to increased sedative effects
The combined use of hawthorn and triprolidine results in enhanced effects due to pharmacodynamic synergism
when combined with rimonabant, there is an increased risk of adverse effects
Through pharmacodynamic synergism, the effects of triprolidine can be enhanced by ashwagandha
Actions and Spectrum:
The action of triprolidine is to bind to histamine receptors in the body, particularly H1 receptors, and prevent histamine from binding to these receptors. This reduces the symptoms of allergies by reducing the amount of histamine released in the body.
The spectrum of triprolidine is primarily focused on treating the symptoms of allergies such as hay fever, allergic rhinitis, and other allergic reactions. It may also be used to treat symptoms associated with the common cold, sinusitis, and other respiratory infections. triprolidine is generally used as a short-term treatment for acute symptoms of allergies and is not intended for long-term use.
Black Box Warning:
triprolidine does not have a black box warning in the United States as it is not currently approved for use by the FDA. However, it is essential to note that antihistamines like triprolidine can cause drowsiness and impair the ability to operate machinery or drive a vehicle. It is also important to avoid consuming alcohol while taking triprolidine as this can increase the risk of drowsiness and other side effects. As with all medications, patients should speak with their healthcare provider about the potential risks and benefits of using triprolidine, as well as any other medications they may be taking.
Contraindication/Caution:
triprolidine is contraindicated in individuals with a known hypersensitivity to the medication or to any of its components. It should also not be used in patients with narrow-angle glaucoma, urinary retention, severe liver disease, or severe asthma. Additionally, triprolidine should be used with caution in patients with a history of seizures, cardiovascular disease, or other medical conditions that may be exacerbated antihistamines.
triprolidine should not be used in children under the age of 6 years old, and should be used with caution in older adults, as they may be more susceptible to the side effects of the medication, such as drowsiness, confusion, and impaired coordination.
Patients should always consult with their healthcare provider before taking triprolidine, especially if they have any underlying medical conditions or are taking other medications, as drug interactions are possible.
Pregnancy warnings:Â Â Â
Pregnancy category: N/A
Lactation:Â Excreted into human milk is unknown
Pregnancy Categories:
Category A:Â Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
Category B: There were a lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.
Category C:Â there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D:Â adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X:Â Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N:Â There is no data available for the drug under this category
Pharmacology:
triprolidine is a first-generation antihistamine that blocks the effects of histamine at H1-receptor sites in the body. Histamine is a chemical released by the body in response to an allergen or other stimuli and is responsible for the symptoms of allergies, such as sneezing, runny nose, itching, and watery eyes.
By blocking histamine’s effects at H1-receptor sites, triprolidine can alleviate allergy symptoms. However, it can also bind to and block other receptors in the body, leading to side effects such as drowsiness, dry mouth, and blurred vision.
Pharmacodynamics:
The pharmacodynamic mechanism of triprolidine involves blocking the action of histamine at the H1 receptor, which reduces the symptoms of allergic reactions, exerts sedative effects by binding to receptors in the brain.
MOA: triprolidine is a first-generation antihistamine that works by blocking the action of histamine, a chemical released during an allergic reaction. Its mechanism of action involves binding to histamine H1 receptors and preventing histamine from binding to and activating the receptor.
Pharmacokinetics:
Absorption
triprolidine is rapidly absorbed from the gastrointestinal tract after oral administration. Its bioavailability is approximately 40 to 50%. Peak plasma concentrations are reached within 2 to 3 hours after ingestion. The drug is highly protein-bound, primarily to albumin, and has a relatively short elimination half-life of approximately 4 hours.
Distribution
triprolidine is widely distributed throughout the body, including the central nervous system.
Metabolism
It is metabolized primarily in the liver by the cytochrome P450 enzyme system, with the major metabolite being desmethyltriprolidine. The metabolites are mainly eliminated in the urine and feces.
Elimination and Excretion
triprolidine is excreted renally, with about 50% of the drug being excreted unchanged in the urine. The remainder is excreted as metabolites. The drug is eliminated relatively quickly, with most of the drug being eliminated within 24 hours of administration.
Administration:Â
triprolidine is typically administered orally in the form of tablets, capsules, or liquid formulations. It is usually taken two to three times a day, depending on the severity of the symptoms, and is typically taken with food to improve absorption.
The dosage of triprolidine will depend on the age, weight, and medical condition of the patient and should be determined by a healthcare provider. Patients should not exceed the recommended dosage, as this can increase the risk of side effects.
Patient information leaflet
Generic Name: triprolidine
Why do we use triprolidine ?
triprolidine is primarily used to treat the symptoms of allergies, such as sneezing, runny nose, itching, and watery eyes. It is an antihistamine medication that works by blocking the effects of histamine, a substance produced by the body in response to an allergic reaction.
Histamine can cause various symptoms associated with allergies, and triprolidine helps reduce these symptoms by preventing histamine from binding to its receptors in the body. This results in decreased histamine release and a reduction in allergic symptoms.
triprolidine is often used to treat seasonal allergies, such as hay fever, and may also be used to relieve symptoms associated with the common cold, sinusitis, and other respiratory infections. It is generally used as a short-term treatment for acute symptoms of allergies and is not intended for long-term use.
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