collagenase

Action and Spectrum

Actions and Spectrum: 

Actions 

collagenase is an enzyme that specifically targets and breaks down collagen, a fibrous protein in connective tissues. Here are the actions and spectrum of collagenase: 

• Collagen Breakdown: The primary action of collagenase is hydrolyzing or cleaving the peptide bonds in collagen molecules. It specifically targets the triple helical structure of collagen and breaks it down into smaller peptides. This enzymatic action helps in the degradation and remodeling of collagen in various tissues. 
• Tissue Remodeling: collagenase is crucial in tissue remodeling processes, like wound healing and tissue repair. Breaking down collagen helps remove damaged or old collagen fibers, facilitating the remodeling and restructuring of tissues during the healing process. 

Spectrum 

collagenase has been studied for its potential in managing keloids and hypertrophic scars characterized by excessive collagen deposition. By breaking down the excess collagen, collagenase may help to soften and flatten these types of scars. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Irritation 

Hypersensitivity disorder 

Burning sensation at the application site 

Black Box Warning

Black Box Warning: 

None 

Contraindication / Caution

Contraindication/Caution: 

• Hypersensitivity 
• Active infections 
• Bleeding disorders 
• Pregnancy 
• Breastfeeding 
• Pediatric Usage 
• Interaction with other medications 

Pregnancy / Lactation

Pregnancy consideration:  

Pregnancy category: C 

Breastfeeding warnings:  

The excretion of the drug in breast milk is unknown. 

Pregnancy category: 

Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology:  

collagenase works by breaking down the triple helical structure of collagen fibers. It cleaves the peptide bonds in collagen molecules, leading to collagen degradation into smaller peptides. This enzymatic activity allows collagenase to target and break down collagen in various tissues selectively.  

Pharmacodynamics: 

The primary pharmacodynamic action of collagenase is the breakdown of collagen fibers. collagenase enzymatically cleaves the peptide bonds within collagen molecules, leading to collagen degradation into smaller peptides. This process helps remodel and modify the extracellular matrix, which is essential for tissue repair and wound healing. 

Pharmacokinetics: 

Absorption 

The absorption of collagenase depends on the route of administration. When administered topically, collagenase is applied directly to the target area, such as a wound or a localized fibrotic tissue. The enzyme acts locally on the collagen fibers in that specific area. 

Distribution 

collagenase is expected to remain localized at the site of administration, where it acts on the collagen fibers. Systemic distribution of collagenase is minimal or negligible, mainly when used topically or injected directly into specific tissues. 

Metabolism 

collagenase is a naturally occurring enzyme expected to undergo degradation and clearance in the body. The exact metabolic pathways of collagenase are not extensively studied or well-documented. 

Elimination and Excretion 

The elimination of collagenase primarily occurs through local clearance at the administration site. As the collagen fibers are broken down and remodeled, the smaller peptides and degradation products are cleared from the body through normal physiological processes. 

Adminstartion

Administration: 

collagenase is available in topical formulations, such as creams, gels, or ointments. These formulations are applied directly to the affected area, such as wounds or scars, to facilitate the enzymatic breakdown of collagen.

Patient Information Leaflet

Patient information leaflet 

Generic Name: collagenase 

Why do we use collagenase? 

collagenase is frequently used in wound care to facilitate the removal of non-viable or necrotic tissue. By breaking down the damaged collagen in the wound bed, collagenase helps to promote the removal of dead tissue, allowing for a clean wound environment and facilitating the natural healing process.