cyclandelate

Action and Spectrum

Actions and Spectrum 

Actions: 

cyclandelate works by relaxing the smooth muscles in the walls of blood vessels, causing vasodilation. This widening of blood vessels reduces peripheral vascular resistance, allowing blood to flow more quickly through the vessels. It, therefore, helps improve blood circulation and alleviate symptoms associated with certain vascular disorders. 

Spectrum: 

cyclandelate’s primary mode of action is related to its effects on smooth muscle relaxation and vasodilation. Unlike antibiotics that target specific bacterial strains or infections, cyclandelate is not an antimicrobial agent with a defined spectrum of activity against specific pathogens. 

Drug Interaction

Adverse Reaction

Frequency not defined 

dizziness 

fast heartbeat 

tingling of the face 

weakness flushing of the face 

headache 

sweating 

Black Box Warning

Black Box Warning: 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindications: 

• Hypersensitivity 
• Coronary Artery Disease 

Cautions: 

• Cardiovascular conditions 
• Hypotension 
• Pregnancy  
• Breastfeeding 
• CNS disorders 
• Liver impairment 
• Drug interactions 

Pregnancy / Lactation

Pregnancy consideration:  

The drug’s effect on the gestating female and the fetus is unknown. 

Breastfeeding warnings:  

No data is available regarding the excretion of the drug in breastilk. 

Pregnancy category: 

Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology:  

• Peripheral Vasodilation: 

cyclandelate primarily acts on the peripheral vasculature, including arteries and veins in the extremities. By dilating these blood vessels, cyclandelate can improve blood circulation and alleviate symptoms of conditions like peripheral vascular disease and Raynaud’s phenomenon. 

• Cerebral Vasodilation: 

cyclandelate’s vasodilatory effects can also extend to cerebral blood vessels. This property might have implications for inadequate cerebral blood flow, such as inevitable headaches or migraines. However, the specific clinical applications for cerebral vasodilation with cyclandelate are limited. 

Pharmacodynamics: 

While cyclandelate is primarily known for its effects on peripheral blood vessels, it can also cause some degree of cerebral vasodilation, which means it can widen blood vessels in the brain. However, the clinical significance of this effect needs to be better established as its peripheral vasodilation properties. 

Pharmacokinetics: 

Absorption 

cyclandelate is typically administered orally in the form of tablets or capsules. After oral administration, the medication is absorbed from the gastrointestinal tract into the bloodstream. The rate and extent of absorption can vary based on factors such as the formulation of the medication and individual patient characteristics. 

Distribution 

Once absorbed into the bloodstream, cyclandelate is distributed throughout the body. It reaches various tissues and organs, including the blood vessels, where it exerts its vasodilatory effects. The extent of distribution depends on factors such as the drug’s chemical properties and tissue perfusion. 

Metabolism 

cyclandelate undergoes metabolism in the liver, breaking it down into metabolites. The specific metabolic pathways & enzymes involved in cyclandelate metabolism have yet to be widely documented in the available literature. 

Elimination and excretion 

The metabolites of cyclandelate and potentially unchanged cyclandelate are eliminated from the body primarily through the kidneys. The exact elimination processes, including the half-life of cyclandelate, can vary among individuals and may depend on factors such as renal function and metabolism. 

Adminstartion

Administration: 

cyclandelate is commonly available as oral tablets or capsules. The dosage form can vary based on the specific brand or manufacturer. cyclandelate is usually taken multiple times a day to maintain its therapeutic effects.

Your healthcare provider will determine the exact dosing schedule. It’s essential to adhere to the prescribed timing to ensure proper blood levels of the medication. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: cyclandelate 

Pronounced as: sye-KLAN-de-late 

Why do we use cyclandelate? 

cyclandelate is often prescribed for individuals with peripheral vascular disease (PVD), a condition with reduced blood flow to the limbs, typically the legs. 

cyclandelate’s ability to promote blood vessel dilation can be beneficial in conditions where improving blood flow is essential, such as promoting healing in wounds or addressing specific circulatory issues.