A Framework for Fitness-for-Purpose and Reuse in Computational Phenotyping
November 17, 2025
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Brand Name :
DTIC-Dome
Synonyms :
Class :
Antineoplastic and Alkylating agents
Brand Name :
DTIC-Dome
Synonyms :
Class :
Antineoplastic and Alkylating agents
Dosage Forms & Strengths
Powder for injection
100mg
200mg
2 - 4.5
mg/kg
Intravenous (IV)
once a day
10
days
; repeat every 4 weeks
OR
250 mg/m2 Intravenous (IV) once a day 5 days; repeat every 3 weeks
150
mg/m^2
Intravenous (IV)
once a day
5
days
in combination therapy; repeat every 4 weeks
OR
375 mg/m2 Intravenous (IV) on Day 1 in combination therapy; repeat every 15 days
Dosage Forms & Strengths
Powder for injection
100mg
200mg
150
mg/m^2
every day
5
days
, repeat every 4 Weeks OR
375 mg/m² IV on Day 1; repeat every 15 Days
150
mg/m^2
every day
5
days
, repeat every 4 Weeks OR
375 mg/m² IV on Day 1; repeat every 15 Days
when bromazepam and dacarbazine are used together, there is a potential reduction in the bromazepam's metabolism
Combining tegafur with dacarbazine can reduce tegafur’s metabolism
When mometasone furoate is used together with dacarbazine, this leads to enhanced risk or seriousness of adverse outcomes
When dacarbazine is used together with somatotropin, this leads to a rise in dacarbazine’s metabolism
When dacarbazine is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
By synergism effects, the toxicity of the other drug increases.
when both drugs combine the risk of both drug increases the toxicity of other by synergism.
both drug toxicity increases by synergism action
when both drugs are combined, there may be an increased risk or severity of adverse effects
when thiotepa and dacarbazine combine, the toxicity of both drugs increases by synergism
when both the drugs are combined, the risk or severity of adverse effects increases
when both drugs are combined, there may be an increased risk or severity of adverse effects
when both drugs are combined, there may be an increased risk or severity of adverse effects
when both drugs are combined, there may be an increased risk or severity of adverse effects
the rate of excretion of aurothioglucose may be reduced with dacarbazine
dacarbazine might lead to a reduction in the rate of excretion of telavancin, potentially leading to elevated levels of serum
the activity of the anthrax vaccine can be reduced when used in combination with dacarbazine
When dacarbazine is aided by hesperetin, it reduces hesperetin’s metabolism
Adverse drug reactions:
Frequency Defined
>10%
Nausea (>90%)
Leukopenia
Thrombocytopenia
Injection site pain
1-10%
Anorexia
Alopecia
Metallic taste
Rash
Photosensitivity
Flu-like syndrome
Frequency Not Defined
Anaphylaxis
Myelosuppression
Photosensitivity (rare)
Cerebral hemorrhage
Hepatic necrosis
Hepatic vein thrombosis
Seizure
Hepatotoxicity
Pregnancy warnings:
AU TGA pregnancy category: D
US FDA pregnancy category: C
Lactation:
Excreted into human milk is Unknown
Pregnancy Categories:
Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester.
Category B: No evidence shown of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a result in humans must take care of potential risks in pregnant women
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Patient Information Leaflet
Generic Name: dacarbazine
Why do we use dacarbazine?
dacarbazine is an Antineoplastic Alkylating agent used to treat malignant melanoma and Hodgkin’s disease.
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