Cystathionine γ-Lyase Identified as a Key Regulator of Memory and Learning
January 1, 2026
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Brand Name :
Zinbryta
Synonyms :
daclizumab
Class :
Monoclonal antibodies, Interleukin inhibitors
Brand Name :
Zinbryta
Synonyms :
daclizumab
Class :
Monoclonal antibodies, Interleukin inhibitors
Dosage Forms & Strengths
Injectable solution
5mg/ml
150mg/ml
150
mg
Solution
Subcutaneous (SC)
once a month
Safety study not established for use in the pediatric population under the age of 17years
Safety study not established for use in geriatric population above the age of 65 years
It may diminish the effects when combined with rozanolixizumab by receptor binding competition
the risk of adverse effects can be increased
the risk of adverse effects can be increased
the risk of infection can be increased
allogeneic processed thymus tissue
a decrease in the therapeutic activity of allogenic processed thymus tissue may be seen
the risk of adverse effects can be increased
the risk of adverse effects can be increased
the risk of adverse effects can be increased
the risk of adverse effects can be increased
the risk of adverse effects can be increased
the risk of adverse effects can be increased
the risk of adverse effects can be increased
the risk of adverse effects can be increased
synthetic conjugated estrogens, a
an increase in thrombogenic activity of daclizumab may be seen
synthetic conjugated estrogens, b
an increase in thrombogenic activity of daclizumab may be seen
the risk of adverse effects can be increased
an increase in the thrombogenic activity of daclizumab may be seen
tick-borne encephalitis vaccine
the therapeutic activity of the tick-borne encephalitis vaccine (whole virus, inactivated) may be reduced
may enhance the immunosuppressive effects of trimetrexate
when both drugs are combined, there may be an increased risk or severity of adverse effects
may enhance the immunosuppressive effects of pemetrexed
Actions and spectrum:
Daclizumab is thought to modulate IL-2-mediated lymphocyte activation by binding to CD25, a subunit of the high-affinity IL-2 receptor. The exact mechanism by which daclizumab causes therapeutic properties in multiple sclerosis is undetermined.
Frequency not defined
Coughing
Chest pain
Vomiting
Shaking or trembling of hands or feet
Shortness of breath
Weakness
Nausea
Vomiting
Frequent urination (rare)
Trouble sleeping
Headache
Pain in the muscle
Oropharyngeal pain
Frequency defined
Lymphadenopathy (1-10%)
Toxic skin eruption (0.1-1%)
Dermatitis (1-10%)
Erythematous rash (1-10%)
Vesicular rash (11%)
Tonsillitis (1-10%)
Decrease in lymphocyte count (1-10%)
Anemia (1-10%)
Depression (1-10%)
Infection of the upper respiratory tract (17%)
Nasopharyngitis (25%)
Black Box Warning
Daclizumab is available only through the REMS program (Risk Evaluation and Mitigation Strategy) because of the risk of hepatic injury and immune-mediated disorders.
Contraindication/Caution:
Contraindication:
Hypersensitivity
Hepatic impairment
Pregnancy consideration:
No adequate data is established for the use of daclizumab in pregnancy
Lactation:
There is no data about the excretion of drugs in breast milk
Pregnancy category:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus `in either the first or second trimester.
Category B: There was a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
Pharmacodynamics:
The mean cell counts of the three main immune subsets—T, B, and NK cells—stayed within normal limits while under ZINBRYTA (daclizumab) treatment. During the first year of treatment, the total lymphocyte, B, and T cell counts are reduced by less than 10% from baseline. About 8–12 weeks after the last ZINBRYTA (daclizumab) (150 mg) dose, total lymphocyte counts got back to baseline.
Pharmacokinetics:
Absorption
The maximum serum concentration of daclizumab at steady state was observed to be 30µg/ml, and 90% bioavailability was seen with subcutaneous administration of 150mg dose.
Distribution
Volume of distribution: 6.34l
Metabolism
Being a protein, daclizumab should be catalyzed to amino acids and peptides similar to endogenous IgG proteins.
Elimination and excretion
Rate of clearance- 0.212 liters/day
Half-life:
21 days
Administration:
Daclizumab should be administered subcutaneously to the patient only by the medical practitioner
Patient information leaflet
Generic Name: daclizumab
Why do we use daclizumab?
Daclizumab is indicated in the treatment of multiple sclerosis, especially relapsing forms. It is an antibody that blocks interleukin-2 receptors.
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