- May 26, 2022
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Brand Name :
Ontak
Synonyms :
denileukin diftitox
Class :
Antineoplastic Agents and Biologic Response Modifiers
Dosage forms & strengths:
Infusion
150 mcg per ml
9
mcg/kg
once a day
or 18 mcg per kg per day by IV infusion given over 30-60 minutes for five days every 21 days course for eight cycles
Renal Dose Adjustments:
No Data available
Liver Dose Adjustments:
No Data available
Dialysis:
No Data available
Precautions:
In 2014, discontinued the marketing of this drug in the US.
Administration advice:
• Do not combine this drug with other medications
• Don’t take this drug through an in-line filter
• should be administered prepared solutions within 6hrs by using a syringe pump/IV infusion bag
when both drugs are combined, there may be an increased risk and severity of life-threatening infections
when both drugs are combined, there may be an increased risk and severity of life-threatening infections
when both drugs are combined, there may be a decreased therapeutic effect of the vaccine
when both drugs are combined, there may be a decreased therapeutic effect of the vaccine
when both drugs are combined, there may be a decreased therapeutic effect of the vaccine
when both drugs are combined, there may be an increased risk of adverse effects
when both drugs are combined, there may be a decreased therapeutic effect of the vaccine
when both drugs are combined, there may be a decreased therapeutic effect of the vaccine
when both drugs are combined, there may be a decreased therapeutic effect of the vaccine
when both drugs are combined, there may be a decreased therapeutic effect of the vaccine
when both drugs are combined, there may be an increased risk of serious infections
when both drugs are combined, there may be a reduced response to the skin test
when both drugs are combined, there may be a decreased therapeutic effect of the vaccine
when both drugs are combined, there may be a decreased therapeutic effect of the vaccine
when both drugs are combined, there may be a reduced response to the skin test
when both drugs are combined, there may be an increased risk of serious infections
when both drugs are combined, there may be an increased risk of serious infections
when both drugs are combined, there may be an increased risk of serious infections
when both drugs are combined, there may be an increased risk of serious infections
Adverse drug reactions:
Frequency defined
>10%
Capillary leak syndrome
Hypotension
Infusion reactions
pyrexia
rigors
fatigue
peripheral edema
Nausea
vomiting
diarrhea
1-10%
Visual changes
Pregnancy warnings:
Breastfeeding warnings:
Pregnancy Categories:
Patient Information Leaflet
Generic Name: Denileukin Diftitox (Rx)
Pronounced: DEN-i-loo-kin DIF-ti-toks
Why do we use Denileukin Diftitox?
denileukin diftitox is an antineoplastic agent, and it is an engineered protein combining interleukin-2 and diphtheria toxin denileukin diftitox works by interfering with the growth of cancer cells, could results in the death of the cancer cells
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