dibrompropamidine

Action and Spectrum

Actions and Spectrum: 

dibrompropamidine is an antimicrobial agent that is commonly used as an eye drop or eye ointment for the treatment of certain eye infections. 

dibrompropamidine is effective against a variety of bacteria, including gram-positive and gram-negative bacteria. It may be used in the treatment of bacterial conjunctivitis and other ocular infections caused by susceptible organisms. 

dibrompropamidine also exhibits activity against some protozoa, such as Acanthamoeba. Acanthamoeba keratitis is a rare but severe eye infection, and dibrompropamidine may be used in its treatment. 

Drug Interaction

Adverse Reaction

Frequency not defined 

stinging or burning 

inflammation of the skin 

skin rash 

irritation or itching 

Black Box Warning

Black box warning: 

None 

Contraindication / Caution

Contraindications/caution: 

• Hypersensitivity or Allergy: Individuals who have a known hypersensitivity or allergy to dibrompropamidine or any of its components should not use the medication.  
• Corneal Epithelial Defects: dibrompropamidine is contraindicated in cases where there are significant corneal epithelial defects. The medication may cause irritation or delayed healing in such situations. 
• Pregnancy and Breastfeeding: The safety of dibrompropamidine use during pregnancy and breastfeeding is not well established. In general, the potential risks and benefits should be carefully considered, and the use of the medication should be discussed with a healthcare professional. 
• Pre-existing Eye Conditions: Caution is advised when using dibrompropamidine in individuals with pre-existing eye conditions, especially those affecting the cornea.  

Pregnancy / Lactation

Pregnancy consideration: Insufficient data available 

Lactation: Excretion of the drug in human breast milk is unknown 

Pregnancy category: 

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category 

Pharmacology

Pharmacology: 

dibrompropamidine exhibits a broad spectrum of activity against microorganisms, including: 

Active against both gram-positive and gram-negative bacteria. It may be used for bacterial conjunctivitis caused by susceptible organisms. 

Effective against certain protozoa, particularly Acanthamoeba. Acanthamoeba keratitis is a rare but serious eye infection, and dibrompropamidine may be used in its treatment. 

Pharmacokinetics: 

Absorption 

dibrompropamidine is typically administered topically as eye drops or ointment. The absorption through the ocular surface is limited, and systemic absorption is minimal. 

Distribution 

After topical administration, the drug is distributed locally in the eye tissues. 

Metabolism and Elimination 

The metabolism and elimination of dibrompropamidine need to be better characterized. Since it is used topically in the eye, systemic metabolism and elimination are likely minimal. 

Adminstartion

Administration: 

It is typically administered as eye drops or eye ointment. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: dibrompropamidine 

Why do we use dibrompropamidine? 

dibrompropamidine is formulated as an eye drop or eye ointment and is primarily used for the treatment of certain eye infections.  

• Bacterial conjunctivitis: dibrompropamidine is used in the treatment of bacterial conjunctivitis.The medication helps to combat the bacteria responsible for the infection. 
• Acanthamoeba Keratitis: dibrompropamidine is employed in the treatment of Acanthamoeba keratitis, a rare but serious eye infection caused by protozoan Acanthamoeba. This condition can be challenging to treat, and dibrompropamidine is one of the agents used to combat the protozoa. 
• Other Eye Infections: In some cases, dibrompropamidine may be prescribed for other types of eye infections where its spectrum of activity against bacteria and protozoa is deemed beneficial. 
• Prevention of Infection: dibrompropamidine may be used prophylactically to prevent eye infections in certain situations, especially in individuals at risk of exposure to infectious agents.