Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
N/A
Synonyms :
dicoumarol
Class :
Vitamin K antagonists
Brand Name :
N/A
Synonyms :
dicoumarol
Class :
Vitamin K antagonists
Not determined Â
Refer to adult dosingÂ
pentamycin increases the therapeutic effectiveness of dicoumarol when used in combination
may enhance the effect of anticoagulants
thrombolytic Agents may enhance the anticoagulant effect of anticoagulants
may enhance the adverse/toxic effect of anticoagulants
may enhance the adverse/toxic effect of anticoagulants
may enhance the adverse/toxic effect of anticoagulants
may enhance the adverse/toxic effect of anticoagulants
may enhance the adverse/toxic effect of anticoagulants
Combining dicoumarol with pranlukast may cause a reduction in the dicoumarol’s metabolism
When dicoumarol is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When dicoumarol is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
when used with dicoumarol, andexanet alfa's therapeutic efficacy may be reduced
When dicoumarol is used together with oleandomycin, this leads to enhanced concentration serum of dicoumarol
When dicoumarol is used together with ridaforolimus, this leads to enhanced concentration serum of dicoumarol
it may increase the action of anticoagulant effect
it may increase the effect of anticoagulants
it may enhance the anticoagulant effect of anticoagulants
it may enhance the anticoagulant effect of anticoagulants
it may enhance the anticoagulant effect of anticoagulants
it may enhance the anticoagulant effect of anticoagulants
it may enhance the anticoagulant effect of anticoagulants
antiplatelet agents increase the effect of anticoagulants
antiplatelet agents increase the effect of anticoagulants
choline magnesium trisalicylate
salicylates may enhance the anticoagulant effect of anticoagulants
may enhance the adverse/toxic effect of anticoagulants
may enhance the adverse/toxic effect of anticoagulants
may enhance the adverse/toxic effect of anticoagulants
may increase the anticoagulant effect of anticoagulants
may increase the anticoagulant effect of anticoagulants
may increase the anticoagulant effect of anticoagulants
may increase the anticoagulant effect of anticoagulants
may increase the anticoagulant effect of anticoagulants
may increase the toxic effect of prostacyclin analogs
may enhance the anticoagulant effect of anticoagulants
may enhance the adverse/toxic effect of anticoagulants
may enhance the adverse/toxic effect of anticoagulants
may enhance the adverse/toxic effect of anticoagulants
may enhance the adverse/toxic effect of anticoagulants
may enhance the adverse/toxic effect of anticoagulants
may enhance the adverse/toxic effect of anticoagulants
may enhance the adverse/toxic effect of anticoagulants
may enhance the adverse/toxic effect of anticoagulants
may increase the anti-platelet effect of anti-coagulants agents
the risk of bleeding may be increased
Actions and SpectrumÂ
dicoumarol exerts its anticoagulant effect by interfering with the normal blood clotting process. It inhibits the activity of vitamin K, which is essential for the synthesis of several clotting factors in the liver. Â
It disrupts the recycling of vitamin K, leading to a deficiency of active vitamin K, and subsequently, a decrease in the production of clotting factors II, VII, IX, and X.
Frequency not defined Â
Hair lossÂ
Decreased appetiteÂ
Change in visionÂ
GasÂ
Black Box WarningÂ
None
Contraindication/Caution:Â
Contraindication:Â
Caution:Â
Pregnancy consideration:Â
Pregnancy category: N/AÂ
Lactation: Excretion into human milk is unknown Â
Pregnancy Categories:        Â
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.Â
Category N: There is no data available for the drug under this category.Â
Pharmacology Â
dicoumarol inhibits the enzyme vitamin K epoxide reductase, which is responsible for converting inactive vitamin K back to its active form. Â
It reduces the availability of active vitamin K in the body, leading to decreased synthesis of clotting factors. It also prolongs the time it takes for blood to clot. Â
PharmacodynamicsÂ
The anticoagulant activity of dicoumarol is monitored through laboratory tests, specifically the prothrombin time (PT) and the international normalized ratio (INR).Â
The PT measures the time it takes for the blood to clot, with results expressed in seconds. The INR is a standardized measure of the PT, allowing for consistent comparisons between different laboratories.Â
PharmacokineticsÂ
Absorption  Â
dicoumarol is absorbed from the gastrointestinal tract after oral intake.Â
DistributionÂ
dicoumarol is distributed to various tissues throughout the body. Â
MetabolismÂ
dicoumarol is primarily metabolized in the liver.Â
Elimination and excretionÂ
dicoumarol is excreted from the body via the kidneys.Â
AdministrationÂ
dicoumarol is available in the form of oral tablets.Â
Patient information leafletÂ
Generic Name: dicoumarolÂ
Why do we use dicoumarol?Â
dicoumarol is used in the blood clotting process. Â
dicoumarol is indicated in atrial fibrillation to reduce the risk of stroke and systemic embolism by preventing the formation of blood clots. dicoumarol is used in the management and prevention of venous thromboembolism.Â
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