dried ferrous sulfate / sodium ascorbate

Action and Spectrum

Actions and Spectrum: 

Actions: 

This supplement is intended to prevent and treat iron-deficiency anemia, which can be particularly problematic when it coexists with a vitamin C deficiency. Iron absorption is improved by the addition of vitamin C. Because of the controlled-release system in place, there is less chance of stomach upset and the iron will be released gradually over a few hours.  

This controlled-release device uses a safe plastic honeycomb that has many tiny iron-containing passageways. The iron is progressively released from the tablet as it passes through the stomach and digestive tract, and the empty honeycomb is eliminated in the stools. 

Spectrum: 

This supplement is intended to prevent and treat iron-deficit anemia, particularly in cases where a vitamin C deficiency is present. 

Drug Interaction

Adverse Reaction

Frequency defined 

>10% 

Haematemesis 

Constipation 

Vomiting 

Allergic reactions 

Black stools 

Feeling sick 

Diarrhea 

Black Box Warning

Black Box Warning: 

The color Ponceau 4R red (E124) used in this product has the potential to produce allergic reactions, including asthma; aspirin allergies are more common in this population. 

Contraindication / Caution

Contraindication/Caution: 

Contraindications 

• Hypersensitivity 
• Children below 12 years 
• Iron overload syndromes 
• Haemochromatosis 
• Intestinal blockage 
• haemosiderosis 

Cautions 

• Renal impairment 
• Iron overload syndromes 
• Haemochromatosis 
• Intestinal blockage 
• haemosiderosis 
• Hepatic impairment 
• Drug interactions 
• Pregnancy  
• Breastfeeding 

Pregnancy / Lactation

Pregnancy consideration:  

Avoid the use of Ferrograd C within the initial thirteen weeks of pregnancy. Following the initial thirteen weeks of pregnancy, it is advisable to consult your doctor before taking Ferrograd C, as an alternative iron supplement containing folic acid may be recommended. Seek advice from your doctor or pharmacist before taking any medication if you plan to breastfeed. 

Breastfeeding warnings:  

No data is available regarding the excretion of drug in breast milk. 

Pregnancy category: 

Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology: 

This drug, an iron supplement, is used to treat or prevent low blood iron levels (such as those resulting from anemia or pregnancy). Iron absorption from the stomach is enhanced by ascorbic acid, sometimes known as vitamin C. 

Pharmacodynamics: 

This medication tackles iron-deficiency anemia by restoring iron stores, fostering the production of red blood cells, and enhancing the transportation of oxygen throughout the body. The incorporation of vitamin C in Ferrograd C elevates the bioavailability of iron, facilitating more efficient absorption by the body. The collaboration between iron and vitamin C in Ferrograd C ensures a holistic strategy for addressing iron deficiency and anemia. Vitamin C plays a vital role in converting ferric iron to the more readily absorbable ferrous form, thereby augmenting the overall absorption of iron. 

Pharmacokinetics: 

Absorption 

Absorption of iron primarily occurs in the small intestine and is subject to factors like dietary composition. Similarly, vitamin C is effectively absorbed in the small intestine. 

Distribution 

After absorption, iron is typically conveyed in the bloodstream, frequently bound to transferrin, a protein that aids in delivering it to diverse tissues. Simultaneously, absorbed vitamin C is transported through the bloodstream by carrier proteins. 

Metabolism 

Iron is integrated into hemoglobin and stored in tissues such as the liver. On the other hand, vitamin C plays a role in numerous metabolic processes, and any surplus amounts are eliminated through urine. 

Elimination and Excretion 

The elimination of iron is not particularly efficient, and any surplus iron may either be stored in tissues or expelled through processes such as menstruation. 

Adminstartion

Administration: 

Always adhere to the prescribed instructions for dried ferrous sulfate / sodium ascorbate provided by your doctor. If you are uncertain, consult your doctor for clarification. 

For adults and children over 12 years, the typical dosage is one tablet daily on an empty stomach. Ensure the tablet is swallowed whole with water and refrain from sucking, chewing, or holding it in your mouth. 

Ferrograd C is not suitable for children under 12 years of age. 

In the event of accidentally taking more than one tablet in a day or if a child has ingested the tablets, seek urgent medical advice, as an overdose, particularly in children, may have serious consequences. 

If you forget to take Ferrograd C on any given day, resume by taking one tablet daily. Avoid taking more than one tablet per day. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: dried ferrous sulfate / sodium ascorbate 

Pronounced: dryd FER-us SUL-fayt/SOH-dee-um uh-SKOR-bayt 

Why do we use dried ferrous sulfate / sodium ascorbate? 

This is a supplement containing iron, utilized for the prevention and treatment of iron-deficiency anemia and vitamin C deficiency when both conditions coexist. The inclusion of vitamin C aids in the absorption of iron by the body.