RyR1 Structural Alterations Explain Statin-Associated Muscle Dysfunction
December 16, 2025
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Brand Name :
Vecredil, Emcredil
Synonyms :
ethacridine
Class :
Abortifacient, Cervical Ripening Agents
Brand Name :
Vecredil, Emcredil
Synonyms :
ethacridine
Class :
Abortifacient, Cervical Ripening Agents
Dosage Forms & Strengths
Solution
50 ml
100 ml
Administer dose of 10 ml intravenously slowly with a Foley catheter in the uterus
Not determined
Refer to adult dosing
Actions and Spectrum
ethacridine works by disrupting the structure and function of microbial cell membranes. It can damage the cell walls of bacteria and disrupt the lipid membranes of viruses. It can help prevent or treat infections by reducing the number of bacteria in the area.
Frequency not defined
Vomiting
Headache
Slow heart rate
Increased heart rate
Nausea
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
ethacridine is damaging microbial cell walls and membranes. It interferes with the integrity and function of these structures, leading to cell death or inactivation.
This disruption of the microbial membrane contributes to its antimicrobial properties.
Pharmacodynamics
ethacridine can inhibit the growth of bacteria by interfering with their cell membrane structure.
In addition to inhibiting bacterial growth, ethacridine can also kill bacteria. It damages ba
Pharmacokinetics
Limited information available on ADME.
Administration
ethacridine is administered as IV infusion and as powder for topical use.
Patient information leaflet
Generic Name: ethacridine
Why do we use ethacridine?
ethacridine is used for second-trimester abortion.
ethacridine is also used as an antiseptic to cure wound and cuts.
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