felypressin

Action and Spectrum

Actions and spectrum: 

Felypressin attaches itself to the V1a vasopressin receptor. This results in the smooth muscle in the vascular bed, particularly the venules, small arterioles, and capillaries, contracting. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Vasoconstriction of coronary artery 

Irritation of eyes 

Allergic reactions on the skin 

Black Box Warning

Black Box Warning  

No special warning is available for this drug 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

Hypersensitivity  

Pregnancy / Lactation

Pregnancy consideration:  

USFDA pregnancy category: the drug is not recommended for use in pregnancy due to its vasoconstriction property 

Lactation:  

Data about the excretion of felypressin into human milk has yet to be studied. 

Pregnancy category:  

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

Category B: There was a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology: 

Felypressin is a synthetic nonapeptide that consists of phenylalanyl, cysteinyl, asparaginyl, cysteinyl, glutamyl, phenylalanyl,  prolyl, lysyl, and glycinamide residues 

Pharmacodynamics: 

Felypressin is a synthetic vasopressin analog that has more vasoconstrictor than antidiuretic properties. Its main application is as a hemostatic. 

Pharmacokinetics: 

ADME properties for felypressin are not documented  

Adminstartion

Administration: 

To be taken intramuscularly 

Patient Information Leaflet

Patient information leaflet 

Generic Name: felypressin 

Why do we use felypressin? 

Felypressin is chemically like vasopressin. It is a synthetic analog of vasopressin. It has less of an antidiuretic effect than vasopressin. It is an ingredient in preparations that have been used to treat oral pain and inflammation, as well as a vasoconstrictor in local anesthetic injections for dental use.