A Milestone Moment: FDA Approves Addyi® for Hypoactive Sexual Desire Disorder in Postmenopausal Women
December 17, 2025
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
Octapressin
Synonyms :
felypressin
Class :
Vasoconstrictors
Brand Name :
Octapressin
Synonyms :
felypressin
Class :
Vasoconstrictors
Dosage Forms and Strengths
Injectable solutions
0.03IU/ml
It is also an ingredient in various preparations that are being used for treating inflammation and pain in the mouth:
Off-label
In combination
Felypressin 0.03IU/mL + prilocaine hydrochloride 30mg intramuscularly
Regular dose: 1ml to 5ml
Max. dose: 10 ml
Indications: It is indicated as a vasoconstrictor in dental procedures, along with prilocaine
Dosage Forms and Strengths
Injectable solutions
0.03IU/ml
It is also an ingredient in various preparations that are being used for treating inflammation and pain in the mouth.:
Off-label
In combination
Felypressin 0.03IU/mL + prilocaine hydrochloride 30mg intramuscularly
For children of age less than 10 years: 1ml to 2ml
For children of age 10 years to 18 years: 1ml to 5ml
Max. dose: 10 ml
Indications: It is indicated as a vasoconstrictor in dental procedures, along with prilocaine
Refer to adult dosing
the risk of adverse effects may be increased
the vasoconstricting activity of felypressin may be increased
the risk of hypertension may be increased
the vasoconstricting activity of felypressin may be increased
the risk of hypertension may be increased
the risk of hypertension may be increased
the vasoconstricting activity of felypressin may be increased
Actions and spectrum:
Felypressin attaches itself to the V1a vasopressin receptor. This results in the smooth muscle in the vascular bed, particularly the venules, small arterioles, and capillaries, contracting.
Frequency not defined
Vasoconstriction of coronary artery
Irritation of eyes
Allergic reactions on the skin
Black Box Warning
No special warning is available for this drug
Contraindication/Caution:
Contraindication:
Hypersensitivity
Pregnancy consideration:
USFDA pregnancy category: the drug is not recommended for use in pregnancy due to its vasoconstriction property
Lactation:
Data about the excretion of felypressin into human milk has yet to be studied.
Pregnancy category:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
Category B: There was a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
Felypressin is a synthetic nonapeptide that consists of phenylalanyl, cysteinyl, asparaginyl, cysteinyl, glutamyl, phenylalanyl, prolyl, lysyl, and glycinamide residues
Pharmacodynamics:
Felypressin is a synthetic vasopressin analog that has more vasoconstrictor than antidiuretic properties. Its main application is as a hemostatic.
Pharmacokinetics:
ADME properties for felypressin are not documented
Administration:
To be taken intramuscularly
Patient information leaflet
Generic Name: felypressin
Why do we use felypressin?
Felypressin is chemically like vasopressin. It is a synthetic analog of vasopressin. It has less of an antidiuretic effect than vasopressin. It is an ingredient in preparations that have been used to treat oral pain and inflammation, as well as a vasoconstrictor in local anesthetic injections for dental use.
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
