Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Lederfen
Synonyms :
fenbufen
Class :
NSAID
Brand Name :
Lederfen
Synonyms :
fenbufen
Class :
NSAID
Dosage forms and strengths Â
Oral tabletÂ
300 mgÂ
450 mgÂ
Take 300 mg during morning hours & and 600 mg at sleep time, or take 450 mg two times a day
Take 300 mg during morning hours & and 600 mg at sleep time, or take 450 mg two times a day
Not indicatedÂ
Refer adult dosingÂ
choline magnesium trisalicylate
NSAIDs may enhance the adverse/toxic effect of Salicylates
it may enhance the antiplatelet effect of Nonsteroidal Anti-Inflammatory Agents
it may enhance the antiplatelet effect of Nonsteroidal Anti-Inflammatory Agents
it may enhance the antiplatelet effect of Nonsteroidal Anti-Inflammatory Agents
it may enhance the antiplatelet effect of Nonsteroidal Anti-Inflammatory Agents
it may enhance the antiplatelet effect of Nonsteroidal Anti-Inflammatory Agents
it May diminish the therapeutic effect of Loop Diuretics
it May diminish the therapeutic effect of Loop Diuretics
it May diminish the therapeutic effect of Loop Diuretics
NSAIDs may enhance the adverse/toxic effect of Bisphosphonate Derivatives
NSAIDs may enhance the adverse/toxic effect of Bisphosphonate Derivatives
NSAIDs may enhance the adverse/toxic effect of Bisphosphonate Derivatives
NSAIDs may enhance the adverse/toxic effect of Bisphosphonate Derivatives
fenbufen has the potential to reduce the rate of excretion of idebenone, leading to an elevation in levels of serum
When loracarbef is used together with fenbufen, the risk or seriousness of nephrotoxicity is enhanced
When fenbufen is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When fenbufen is used together with piroxicam, this leads to enhanced risk or seriousness of adverse outcomes
When fenbufen is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When fenbufen is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
fenbufen leads to a reduction in the rate of excretion of nitric oxide, which leads to an increased level of serum
When fenbufen is used together with nifenazone, this leads to enhanced risk or seriousness of adverse events
When fenbufen is used together with diazoxide, this leads to reduction in therapeutic effectiveness of diazoxide
it may increase the effect of serotonergic agents
When aceclofenac is used together with fenbufen, this leads to enhanced risk or seriousness of adverse events
When acetaminophen is used together with fenbufen, this leads to enhanced risk or seriousness of adverse events
When acetylsalicylic acid is used together with fenbufen, this leads to enhanced risk or seriousness of adverse events
When alclofenac is used together with fenbufen, this leads to enhanced risk or seriousness of adverse events
When alendronic acid is used together with fenbufen, this leads to enhanced risk or seriousness of adverse events
Actions and Spectrum:Â
Action:Â
The action of fenbufen involves inhibiting the activity of an enzyme called cyclooxygenase (COX), specifically the COX-1 and COX-2 enzymes. By blocking the action of COX enzymes, fenbufen reduces the production of prostaglandins, thereby alleviating inflammation, reducing pain, and lowering fever.Â
Frequency not defined Â
Trouble sleepingÂ
Stomach crampsÂ
Sensation of spinningÂ
HeartburnÂ
DizzinessÂ
Black Box Warning:Â Â
None
Contraindication/Caution:Â Â
Hypersensitivity: Individuals who have a known hypersensitivity or allergic reaction to fenbufen or any components of its formulation should avoid its use.Â
Active peptic ulcer disease: Fenbufen can exacerbate peptic ulcers or cause gastrointestinal bleeding. Therefore, it is contraindicated in individuals with a history of recurrent peptic ulcers.Â
Gastrointestinal bleeding: Patients with a history of gastrointestinal bleeding or perforation associated with NSAID use should avoid fenbufen.Â
Severe heart failure: NSAIDs like fenbufen can cause sodium and fluid retention, which may exacerbate heart failure. Hence, it is contraindicated in patients with severe heart failure.Â
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology: Fenbufen is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits analgesic, anti-inflammatory, and antipyretic properties.Â
Pharmacodynamics:Â Â
Anti-inflammatory effects: Fenbufen decreases inflammation by inhibiting the synthesis of prostaglandins that cause swelling, redness, and pain at the site of inflammation.Â
Pharmacokinetics:Â
AbsorptionÂ
Fenbufen is well-absorbed from the gastrointestinal tract after oral administration.Â
DistributionÂ
It binds extensively to plasma proteins and is distributed widely throughout the body.Â
MetabolismÂ
Fenbufen undergoes hepatic metabolism via conjugation and oxidation pathways.Â
Excretion and EliminationÂ
The medication and its byproducts are mainly eliminated through the urinary system.Â
Administration: Â
Fenbufen was typically administered orally in the form of tablets or capsules. It was usually recommended to take it with a full glass of water and with or after food to minimize stomach upset.Â
Patient information leafletÂ
Generic Name: fenbufenÂ
Why do we use fenbufen? Â
Fenbufen was used to alleviate various types of mild-moderate pain like muscle pain, dental pain, headaches, menstrual cramps, and arthritis-related pain.Â
It was effective in reducing inflammation caused by inflammatory disorders. Like other NSAIDs, fenbufen was used to reduce fever in individuals suffering from febrile conditions.Â
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