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Brand Name :
N/A
Synonyms :
flunoxaprofen
Class :
NSAID
Brand Name :
N/A
Synonyms :
flunoxaprofen
Class :
NSAID
Dosage forms and strengths Â
Oral tabletÂ
100 mgÂ
In vivo, data suggests taking 100 mg orally two times daily
The treatment duration is sixty days
In vivo, data suggests taking 100 mg orally two times daily
The treatment duration is sixty days
Not indicatedÂ
Refer adult dosingÂ
When amitriptyline is used together with flunoxaprofen, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When amoxapine is used together with flunoxaprofen, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When butriptyline is used together with flunoxaprofen, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When desipramine is used together with flunoxaprofen, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When dibenzepin is used together with flunoxaprofen, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When dosulepin is used together with flunoxaprofen, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When doxepin is used together with flunoxaprofen, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When imipramine is used together with flunoxaprofen, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When nortriptyline is used together with flunoxaprofen, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When protriptyline is used together with flunoxaprofen, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When trimipramine is used together with flunoxaprofen, this leads to enhanced risk or seriousness of gastrointestinal bleeding
Actions and Spectrum:Â
Action:Â
Flunoxaprofen, a nonsteroidal anti-inflammatory drug, exhibits its pharmacological action through the inhibition of leukotriene synthesis.Â
Spectrum:Â
Pain Management: Flunoxaprofen is used to treat mild to severe pain, such as that caused by conditions like arthritis, menstrual cramps, dental pain, muscular aches, and other types of inflammatory or painful conditions.Â
Anti-inflammatory: Its anti-inflammatory properties are effective in reducing swelling, tenderness, and joint stiffness associated with conditions like rheumatoid arthritis and osteoarthritis.Â
Frequency not defined Â
Nausea Â
Vomiting Â
DiarrheaÂ
Abdominal painÂ
Dizziness Â
Black Box Warning:Â Â
None
Contraindication/Caution:Â Â
Allergy or hypersensitivity: Individuals who have a known hypersensitivity or allergy to flunoxaprofen or any component should avoid its use.Â
Bleeding disorders: Flunoxaprofen should be taken with caution in those with bleeding problems or those on anticoagulant drugs since it can increase the risk of bleeding.Â
Renal impairment: Flunoxaprofen can affect kidney function, and its use might be contraindicated or require dosage adjustments in individuals with existing kidney problems.Â
Pregnancy and breastfeeding: Flunoxaprofen is generally not recommended during pregnancy, particularly in the third trimester, and caution is advised during breastfeeding.Â
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology: Â
Flunoxaprofen is chiral NSAID.Â
Pharmacodynamics:Â Â
Flunoxaprofen, a nonsteroidal anti-inflammatory drug, exhibits its pharmacological action through the inhibition of leukotriene synthesis. Â
Pharmacokinetics:Â
AbsorptionÂ
Flunoxaprofen was well absorbed from the gastrointestinal tract, reaching peak plasma concentrations within 2-3 hours after oral administration.Â
DistributionÂ
It binds extensively to plasma proteins, influencing its distribution throughout the body.Â
MetabolismÂ
Flunoxaprofen undergoes significant metabolism in the liver, primarily through N-hydroxylation and conjugation.Â
Excretion and EliminationÂ
Most of the metabolites were eliminated in the urine, with a small portion eliminated in the feces.Â
Administration: Â
The route of administration is oral.Â
The healthcare provider determines the frequency and dose based on the condition being treated.Â
Patient information leafletÂ
Generic Name: flunoxaprofenÂ
Why do we use flunoxaprofen? Â
Flunoxaprofen was effective in managing pain, stiffness, and swelling in people with rheumatoid arthritis & osteoarthritis.Â
Flunoxaprofen could help alleviate pain and cramping associated with menstrual periods.Â
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