formaldehyde topical

Action and Spectrum

Actions and spectrum: 

Actions: 

• Antimicrobial: formaldehyde topical works by denaturing proteins and disrupting the cellular structure of microorganisms, leading to their inactivation or death. It helps to prevent and treat infections by reducing the growth and spread of microorganisms on the skin. 
• Antipruritic: formaldehyde topical can help relieve itching and irritation associated with certain skin conditions, such as dermatitis or insect bites. It has a soothing effect on the skin and can provide temporary relief from itching. 

Spectrum: formaldehyde topical has a broad spectrum of antimicrobial activity. It is effective against various bacteria, including both Gram-positive and Gram-negative strains. It also exhibits antifungal activity against common fungi, such as Candida species. Furthermore, formaldehyde has been shown to have antiviral properties against some viruses. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Dermatitis 

Laryngospasm 

Skin irritation 

Wheezing 

Black Box Warning

Black Box Warning: 

formaldehyde topical does not have any black box warning. 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• Allergy or hypersensitivity: Individuals with a known allergy or hypersensitivity to formaldehyde should avoid direct contact with formaldehyde topical or any products containing formaldehyde. 
• Skin conditions: formaldehyde topical may exacerbate certain pre-existing skin conditions, such as eczema, dermatitis, or open wounds. It is not recommended for use on compromised or damaged skin. 
• Pregnancy and lactation: The use of formaldehyde topical during pregnancy and lactation should be approached with caution. 

Caution: 

• Irritation and sensitization: formaldehyde is a strong irritant and sensitizer. Prolonged or excessive exposure to formaldehyde can cause skin irritation, burns, and allergic reactions. Therefore, caution should be exercised when using formaldehyde-containing products on the skin, and any signs of irritation or adverse reactions should be promptly addressed. 
• Avoid contact with eyes and mucous membranes: formaldehyde should not come into contact with the eyes or mucous membranes, as it may cause severe irritation and damage. If accidental contact occurs, thorough rinsing with water is recommended, and medical attention should be sought if necessary. 
• Avoid use on broken or damaged skin: formaldehyde topical is not recommended for use on broken or damaged skin, as it can cause further irritation and delay the healing process. It is important to ensure that the skin is intact before applying any formaldehyde-containing products. 
• Ventilation and proper handling: When using formaldehyde-containing products, it is important to ensure proper ventilation in the area to minimize exposure to the fumes. Additionally, it is crucial to follow proper handling procedures and use personal protective equipment (PPE) as recommended to minimize the risk of inhalation or skin contact. 

Comorbidities: 

• Dermatitis: Individuals with a history of dermatitis or other skin conditions characterized by inflammation, such as eczema or psoriasis, may be at increased risk of developing skin irritation or exacerbation of their condition when exposed to formaldehyde topical. 
• Asthma and respiratory conditions: formaldehyde is known to be a respiratory irritant and can trigger or worsen symptoms in individuals with asthma or other respiratory conditions. Individuals with such conditions may be more sensitive to formaldehyde exposure and should take caution when using formaldehyde-containing products. 
• Allergies: Some individuals may have specific allergies to formaldehyde or formaldehyde-releasing substances. These individuals may experience allergic reactions, including skin redness, itching, rash, or respiratory symptoms, when exposed to formaldehyde topical. 

Pregnancy / Lactation

Pregnancy consideration: Pregnancy Category: C 

Lactation: distributed in breast milk: unknown  

Pregnancy category: 

• Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 
• <b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 
• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   
• Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 
• Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology: 

formaldehyde topical is a strong disinfectant and preservative agent. It works by releasing formaldehyde gas, which has antimicrobial properties. When applied topically, formaldehyde can kill or inhibit the growth of microorganisms like bacteria, fungi, and viruses. 

formaldehyde acts by denaturing proteins and disrupting the structure and function of microbial cells. It can penetrate walls of microorganisms and interfere with essential cellular processes, leading to their death or inhibition of growth. 

In addition to its antimicrobial properties, formaldehyde also has astringent and keratolytic effects. It can cause tissue shrinkage and coagulation of proteins, which can help in reducing inflammation, itching, and promoting wound healing.  

Pharmacodynamics: 

• The pharmacodynamics of formaldehyde topical primarily involve its antimicrobial and astringent properties. As a disinfectant, formaldehyde acts by denaturing proteins and disrupting the structure and function of microbial cells. This leads to the killing or inhibition of the growth of microorganisms like bacteria, fungi, and viruses. 
• formaldehyde also has astringent effects, which means it causes tissue shrinkage and coagulation of proteins. This can help in reducing inflammation and promoting wound healing. Additionally, the astringent properties of formaldehyde can help in reducing itching and other symptoms associated with certain skin conditions. 

Pharmacokinetics: 

Absorption 

When applied topically, formaldehyde may be minimally absorbed through the skin. However, the exact extent of absorption is limited, and formaldehyde is primarily known for its local effects on the applied area. 

Distribution 

If formaldehyde is absorbed through the skin, it is likely to distribute throughout the body. However, systemic distribution is minimal due to its rapid metabolism and clearance. 

Metabolism 

formaldehyde undergoes rapid metabolism in the body. It is primarily metabolized to formate, a nontoxic substance, through various metabolic pathways, including oxidation by formaldehyde dehydrogenase. The metabolism of formaldehyde is a well-regulated process in the body. 

Elimination and excretion 

The primary excretion pathway for formaldehyde and its metabolites is through urine. formaldehyde is rapidly converted to formate, which is further metabolized and excreted in the urine. 

Adminstartion

Administration: 

• Cleanse the affected area: Start by cleaning the area thoroughly with mild soap and water, or as directed by your healthcare professional. 
• Apply a thin layer: Apply a thin layer of the formaldehyde topical product to the affected area using clean hands, a cotton ball, or a sterile applicator, as appropriate. Avoid excessive application and ensure even coverage. 
• Follow product instructions: Follow the specific instructions provided with the formaldehyde topical product. This may include information on frequency of application, duration of use, and any additional precautions or warnings. 
• Avoid contact to eyes and mucous membranes: Take care to avoid contact with the eyes, mouth, and other mucous membranes.  
• Discontinue use if irritation occurs: If you experience any skin irritation, redness, or other adverse reactions, discontinue use, and seek medical advice. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: formaldehyde topical 

Pronounced: (for-MAL-deh-hahyd)  

Why do we use formaldehyde topical? 

• Wound care: formaldehyde may be used as an ingredient in certain wound care products to help prevent infection and promote healing. 
• Antifungal treatment: formaldehyde has antifungal properties and may be used in the treatment of fungal infections, such as athlete’s foot or fungal nail infections. 
• Nail hardening: formaldehyde-based solutions or nail hardeners may be used to strengthen and harden nails, particularly in cases of weak or brittle nails. 
• Preservative: In some topical formulations, formaldehyde may be used as a preservative to prevent from microbial growth and maintain product stability.