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Brand Name :
Nulibry
Synonyms :
fosdenopterin
Class :
Metabolic enzymes
Brand Name :
Nulibry
Synonyms :
fosdenopterin
Class :
Metabolic enzymes
Dosage forms & Strengths:
Adult:
Refer to the pediatric dosing
Dosage forms & Strengths:
Lyophilized powder for injection
9.5 mg
Molybdenum Cofactor Deficiency (MoCD) Type A
For 1-3 months: 0.7-0.9 mg/kg intravenously each day
For more than 1 year: 0.9 mg/kg intravenously each day
Refer to the pediatric dosing
fosdenopterin may have antimicrobial and anti-inflammatory properties. It inhibits the growth of certain types of bacteria, including Escherichia coli and Pseudomonas aeruginosa.
>10%:
Pyrexia (78%)
Pneumonia (44%)
Vomiting (44%)
Gastroenteritis (33%)
Diarrhea (33%)
Abdominal pain (22%)
Viral tonsillitis (22%)
Rash maculopapular (22%)
Eye swelling (22%)
Agitation (22%)
fosdenopterin should not be used in people hypersensitive to the drug itself.
Pregnancy consideration:
No data is available regarding the use of the drug during pregnancy.
Breastfeeding warnings:
No data is available regarding the secretion of the drug in breast milk.
Pregnancy category:
Absorption
The peak plasma concentration of fosdenopterin is 285 ng/ml for 0.075 mg/kg dose. The value of the area under the curve is 285 ng/ml.
Distribution
The volume of distribution is 300 ml/kg, and bound protein is 6-12%.
Metabolism
The drug is metabolized through a nonenzymatic degradation process to compound Z.
Elimination and excretion
The drug’s half-life is 1.2-1.7 hours, and total body clearance is 167-195 mL/hr/kg.
Patient information leaflet
Generic Name: fosdenopterin
Pronounced: fos-den-op-ter-in
Why do we use fosdenopterin?
fosdenopterin helps treat Molybdenum Cofactor Deficiency.
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