gallopamil

Action and Spectrum

Actions and Spectrum 

gallopamil causes relaxation of the smooth muscles in the walls of blood vessels which leads into vasodilation.  

This dilation of blood vessels can reduce blood pressure and increase blood flow to the heart muscle.

Drug Interaction

Adverse Reaction

Frequency not defined  

Nausea or vertigo 

Headache 

Hypotension 

Dizziness 

Flushing 

Bradycardia arrhythmias 

CHF 

AV block 

Allergic skin reactions 

Constipation 

Ankle oedema 

Gingival hyperplasia 

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• gallopamil should not be used in individuals who have a known hypersensitivity or allergy to any other ingredients.  
• gallopamil is contraindicated in patients with sick sinus syndrome. 

Caution: 

• Patients with bradyarrhythmias should take caution when using gallopamil. 
• Patients with electrolyte imbalances should take caution.

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

gallopamil decreases the influx of calcium ions into cardiac muscle cells, which results in a reduction in the force of cardiac contraction. This effect may be useful in conditions with excessive contraction of the heart muscle such as arrhythmias. 

Pharmacodynamics 

gallopamil prolongs the action of cardiac cells, which can contribute to its antiarrhythmic effects by delaying repolarization. 

It also slows the conduction of electrical impulses through the atrioventricular (AV) node. 

Pharmacokinetics 

Limited information available on ADME 

Adminstartion

Administration 

gallopamil is administered orally in the form of tablets.

Patient Information Leaflet

Patient information leaflet 

Generic Name: gallopamil  

Why do we use gallopamil? 

gallopamil is used to manage stable angina pectoris, a condition characterized by chest pain or discomfort caused by reduced blood flow to the heart muscle. gallopamil is used to treat certain supraventricular arrhythmias, including atrial fibrillation.