gestrinone

Action and Spectrum

Actions and Spectrum 

The progestogenic action of gestrinone allows it to mimic the effects of progesterone. The menstrual cycle, pregnancy, and other reproductive processes all involve progesterone. The progestogenic actions of gestrinone can decrease ovulation and assist control the menstrual cycle.

Drug Interaction

Adverse Reaction

Frequency not defined  

Acne 

Weight gain 

Hirsutism 

Menstrual disturbances 

Oily skin  

Fluid retention  

GI disturbances  

Altered libido 

Hot flushes 

Voice change  

Headache 

Breast size reduction 

Muscle cramp 

Depression 

Arthralgia 

Nervousness 

Change in appetite 

Black Box Warning

Black Box Warning 

None

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• gestrinone can have effects on liver function, so individuals with a history of liver disorders or impaired liver function should generally avoid its use. 
• Individuals with a history of thromboembolic events may be advised to avoid gestrinone. 

Caution: 

• gestrinone should be used cautiously in individuals with a history of hormone-dependent cancers. 
• Individuals with a history of psychiatric disorders should be monitored for any changes in mood or mental well-being. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

Progesterone-like progestogenic actions are displayed by gestrinone. Target tissues bind to include the uterus and ovaries contain progesterone receptors.  

Inhibiting the production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) is the result of this progestogenic action’s inhibition of gonadotropin-releasing hormone (GnRH) secretion. 

Pharmacodynamics 

gestrinone also has androgenic activity so it can bind to and activate androgen receptors.  

This action contributes to its efficacy in treating conditions like endometriosis and fibrocystic breast disease.  

Pharmacokinetics 

Absorption   

gestrinone is absorbed through the gastrointestinal tract and enters the bloodstream.  

Distribution 

gestrinone is distributed throughout the body via the circulatory system.  

Metabolism 

gestrinone undergoes extensive metabolism in the liver.  

Elimination and excretion 

gestrinone is eliminated from the body primarily through the urine and feces.

Adminstartion

Administration 

gestrinone is typically administered orally in the form of tablets. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: gestrinone 

Why do we use gestrinone? 

gestrinone has been used to manage endometriosis in this condition the tissue like the lining of the uterus grows outside the uterus.  

gestrinone is used for various medical purposes related to gynecology.