haloprogin

Action and Spectrum

Actions and Spectrum 

Actions: 

haloprogin belongs to the class of antifungal medications known as halogenated phenols. It exerts its antifungal effects by disrupting fungal cell membranes and interfering with the synthesis of fungal cell wall components. This disruption ultimately leads to the death of the fungal cells. 

Spectrum: 

haloprogin’s spectrum of antifungal activity is limited to certain types of fungi, primarily dermatophytes, and yeast species. Dermatophytes are fungi that cause skin, hair, and nail infections, such as athlete’s foot and ringworm. Some yeast species, such as Candida, are also susceptible to haloprogin. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Vesiculation 

Irritation 

Burning 

Black Box Warning

Black Box Warning: 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindications: 

• QT prolongation 
• Pre-existing cardiac conditions 
• Concomitant medicines 

Cautions: 

• Elderly Patients 
• Children  
• Renal impairment 
• Drug interactions 
• Lifestyle factors 

Pregnancy / Lactation

Pregnancy consideration:  

Pregnancy Category: B 

Breastfeeding warnings:  

No data is available regarding the excretion of drug in breast milk.  

Pregnancy category: 

Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology:  

haloprogin exerts its antifungal effects by disrupting the integrity of fungal cell membranes and interfering with the synthesis of fungal cell wall components. This disruption ultimately leads to the death of the fungal cells. 

Pharmacodynamics: 

haloprogin’s cuts off the oxygen supply for the yeasts, causing their lysis. 

Pharmacokinetics: 

Absorption 

Topical antifungal medications like haloprogin are applied directly to the skin or affected area. Their absorption through the skin is generally limited, as they are designed to have local effects.  

Distribution 

Topical medications like haloprogin remain primarily at the application site and have limited distribution throughout the body. Systemic distribution is minimal due to the localized nature of their use. 

Metabolism 

Because topical medications like haloprogin are not significantly absorbed into the bloodstream, they do not undergo extensive metabolism in the liver or elimination through the kidneys.  

Elimination and Excretion 

haloprogin is typically broken down and excreted at the application site or removed during routine skin shedding. 

Adminstartion

Patient Information Leaflet

Patient information leaflet 

Generic Name: haloprogin 

Pronounced as: hal-o-pro-gin 

Why do we use haloprogin? 

• Antifungal Activity: haloprogin combats fungal infections caused by dermatophytes and some yeast species. These infections include conditions like athlete’s foot, ringworm, and fungal nail infections. 
• Topical Application: haloprogin was formulated into topical creams, ointments, and solutions for external use. Its application directly to the affected skin or nails allowed for localized treatment of fungal infections.