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Brand Name :
Hirudoid
Synonyms :
heparinoid
Class :
Blood modifier agent, Antithrombotic agent, Heparin anticoagulant, Anti-inflammatory
Brand Name :
Hirudoid
Synonyms :
heparinoid
Class :
Blood modifier agent, Antithrombotic agent, Heparin anticoagulant, Anti-inflammatory
Dosage Forms & Strengths
Topical (cutaneous)
0.3% w/w (gel or cream)
Dosage Forms & Strengths
Topical (cutaneous)
0.3% w/w (gel or cream)
Refer to the adult dosing
Actions:
The substance has heparin-like properties. It reduces inflammation, fluid buildup, and blood clotting. It slows coagulation during injury or inflammation. This prevents clots and speeds up bruise healing. It also decreases swelling and relieves inflammation-related discomfort.
Spectrum:
The cream deeply penetrates the skin. It aids in new tissue formation that connects everything. It prevents clot formation and reduces existing clots. Additionally, it alleviates tension and pain. It reduces leg heaviness. Swelling and bruises diminish. Blood flow improves, resulting in healthier skin.
Frequency not defined
Local skin irritation (redness)
Black Box Warning:
Seek immediate medical attention if you experience blue skin discoloration, blue lips, swollen mouth or throat, breathing difficulties, throat tightness, confusion, sleepiness, dizziness, fainting, or children becoming unusually limp or unresponsive. These could indicate a severe allergic reaction requiring urgent hospital care. A rash may also appear. Keep this medicine out of children’s reach and sight. Do not use it on large skin areas, open wounds, or sensitive areas like eyes, lips, or genitals.
Contraindications
Cautions
Pregnancy consideration:
No data is available regarding the administration of the drug during pregnancy.
Breastfeeding warnings:
No data is available regarding the excretion of drug in breast milk.
Pregnancy category:
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.
<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology:
A key trait of heparinoids is their capacity to absorb water. They can dissolve connective tissues. This diminishes redness and smoothens skin. Heparinoids foster rapid fluid uptake from tissues. They augment near-surface blood circulation. Hence, they’re beneficial for treating vein inflammation.
Pharmacodynamics:
When applied topically, heparinoids exhibit anti-inflammatory properties. They slightly reduce PGE2 production and indirectly impact LTB4. Acting as thrombolytic agents, they enhance urokinase activity. Furthermore, heparinoids inhibit hyaluronidase, functioning as anti-exudative agents.
Pharmacokinetics:
Elimination and Excretion
Heparinoids are primarily eliminated through urine. In urine, they are partly broken down and partly unchanged. This facilitates removal of heparinoids from the body. It aids in clearing and eliminating them from the system.
Administration:
Apply a small quantity of the cream over the affected area. Do this two to three times daily. Gentle massaging aids complete absorption. The required amount varies from three to five centimeters, contingent upon the size of the affected region.
Patient information leaflet
Generic Name: heparinoid
Pronounced: hep-uh-rih-noid
Why do we use heparinoid?
Heparinoids are medications similar to heparin that thin blood. They enhance blood flow and prevent clots. Heparinoid creams and ointments can alleviate varicose veins, hemorrhoids, or superficial vein swelling. These treatments reduce swelling, ease pain, and improve circulation. Some skincare products also contain heparinoids for potential skin benefits. Their primary objective is promoting blood movement and preventing clot formation.
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