hepatitis A vaccine inactivated

Action and Spectrum

Actions and Spectrum: 

Actions: 

The way the inactivated hepatitis A vaccine functions is by inducing the production of antibodies by the immune system, which will neutralize and eliminate the virus and end the hepatitis A illness. 

Spectrum: 

Preventing hepatitis A virus (HAV) infection is the main goal of the inactivated hepatitis A vaccination. The liver is impacted by the viral virus hepatitis A, which is usually contracted by consuming tainted food or water. Long-term immunity, decreased illness severity, outbreak prevention, herd immunity, travel medicine, integration into regular immunization schedules, post-exposure prophylaxis, protection in high-risk groups, safe and well-tolerated are all included in the range. 

Drug Interaction

Adverse Reaction

Frequency defined 

>10% 

Fever (9-11%) 

Erythema (1-22%) 

Swelling (9-11%) 

Injection site tenderness (3-56%) 

Warmth (1-17%) 

Anorexia (1-19%) 

Irritability (11-36%) 

Headache (1-16%) 

1-10% 

Crying (2%) 

Diarrhea (1-6%) 

URI (1-10%) 

Rhinorrhea (6%) 

Otitis media (8%) 

Rash (1-5%) 

Fever (3%) 

Cough (1-5%) 

Vomiting (1-4%)  

<1% 

Vertigo 

Hematoma 

Photophobia 

Raised CPK 

Black Box Warning

Black Box Warning: 

If you have a known allergy to any of the vaccine’s ingredients or any other products, notify your doctor before receiving this shot. Patients with an acute febrile illness will not get hepatitis A vaccine inactivated.

Inform your physician if you are expecting or nursing a child. Women who are expecting or nursing should not receive the vaccination unless necessary. 

Contraindication / Caution

Contraindication/Caution: 

Contraindications 

• Hypersensitivity 

Cautions 

• Allergic reactions 
• Syncope 
• Altered immunocompetence 
• Limitations of vaccine effectiveness 
• Pregnancy 
• Lactation 
• Geriatrics 
• Drug interactions 

Pregnancy / Lactation

Pregnancy consideration:  

No data is available regarding the administration of the drug during pregnancy. 

Breastfeeding warnings:  

No data is available regarding the excretion of drug in breast milk. 

Pregnancy category: 

Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology: 

Hepatitis A virus (HAV) attenuated strain that promotes active immunity 

Pharmacodynamics: 

The picornavirus family includes the virus that causes hepatitis A. It is one of several hepatitis viruses that can lead to liver damage and systemic illness. 

Hepatitis A typically takes 28 days to incubate (range: 15 to 50 days).1. Hepatitis A infections can progress from asymptomatic illness to icteric hepatitis and even death, due to their incredibly varied nature. 

Antibodies against HAV offer defense against hepatitis A infection. The lowest titer required to provide protection hasn’t been identified, yet. 

Pharmacokinetics: 

N/A 

Adminstartion

Administration: 

Dilution not considered. 

Before administering, give the vial or syringe a good shake to produce a somewhat opaque, white solution. 

If the suspension doesn’t seem uniform, there are still extraneous particles present, or there is visible discoloration, discard. 

Administer in the deltoid region to adults, adolescents, and children under the age of two. 

Children between the ages of 12 and 23 months: Apply to the outside of the thigh. 

At 2–8°C (36–46°F), refrigerate.  

If the vaccination has been frozen, discard it immediately as freezing reduces its efficacy. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: hepatitis A vaccine inactivated 

Pronounced: heh-puh-TY-tis A vax-EEN in-AK-tuh-vey-ted 

Why do we use hepatitis A vaccine inactivated? 

vaccination containing an inactivated virus. The purpose of the inactivated hepatitis A virus vaccine is to induce active immunity to HAV infection by containing attenuated, cell culture-adapted hepatitis A virus (HAV).