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Brand Name :
Synvisc
Synonyms :
hylan g-f 20
Class :
Viscosupplementation agents, Intra-articular agents, and cross-linked hyaluronic acid derivatives
Brand Name :
Synvisc
Synonyms :
hylan g-f 20
Class :
Viscosupplementation agents, Intra-articular agents, and cross-linked hyaluronic acid derivatives
Dosage Forms & StrengthsÂ
Injectable solution (intra-articular)Â
16 mg/2 mLÂ
48 mg/6 mLÂ
Age: > 21
16 mg into the knee once a week for three weeks
Safety and efficacy are not studiedÂ
Refer to the adult dosingÂ
Actions and Spectrum:Â
It enhances the knee synovial fluid capacity to absorb shock and restores which reduces discomfort.Â
It also lessens gastrointestinal adverse effects and helps delay knee replacement surgery.Â
Frequency not definedÂ
PainÂ
NauseaÂ
Muscle painÂ
ParesthesiaÂ
Infection of the jointÂ
TachycardiaÂ
Peripheral edemaÂ
TirednessÂ
Generalized urticariaÂ
TonsillitisÂ
HemorrhoidsÂ
Black Box Warning:Â
It shows serious adverse events.
Contraindication/Caution:Â
ContraindicationsÂ
HypersensitivityÂ
CautionsÂ
Renal impairmentÂ
Blood clotting disorderÂ
Pregnancy Warnings:Â
Pregnancy category: Not assignedÂ
Lactation:Â
Excretion of the drug into human breast milk is unknown
Pregnancy Categories:Â
Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester.Â
<b>Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women.Â
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.Â
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.Â
Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women.Â
Category N: There is no data available for the drug under this category.Â
Pharmacology:Â
It is a viscosupplementation treatment for knee pain due to osteoarthritis. Â
Pharmacodynamics:Â
It consists of hylan A fluid, hylan B gel, and saltwater derived from hyaluronan found in chicken combs. The treatment aims to replace damaged synovial fluid with a substance resembling that in healthy joints in 18- to 27-year-olds.Â
Pharmacokinetics:Â
Elimination and ExcretionÂ
half-life is 7.88.8 days
Administration:Â
The route of administration is intraarticular given for three weeks requires careful aseptic approach. In order to prevent using the same syringe for both injections, synovial fluid must be removed using an 18-22 gauge needle prior to each injection.Â
Patient information leafletÂ
Generic Name: hylan g-f 20Â
Pronounced: HIGH-lan jee eff twen-teeÂ
Why do we use hylan g-f 20?Â
Hylan G-F 20 treats osteoarthritis in the knee disorder marked by a reduction in synovial fluid helps to enhance joint functionality, reduce discomfort, and increase mobility.Â
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