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Brand Name :
Bandronat, Bonviva, Lasibon
Synonyms :
ibandronic acid, ibandronate
Class :
Musculo-skeletal system agent, Osteoporosis agent
Dosage forms and strengths
Oral tablet
150 mg
Not indicated
the risk or intensity of gastrointestinal bleeding can be heightened when acemetacin is combined with ibandronate
the risk or intensity of gastrointestinal bleeding can be heightened when acetylsalicylic acid is combined with ibandronate
the risk or intensity of gastrointestinal bleeding can be heightened when aceclofenac is combined with ibandronate
the risk or intensity of myopathy, rhabdomyolysis, and myoglobinuria can be heightened when ibandronate is combined with acipimox
the risk or intensity of QTc prolongation can be heightened when ibandronate is combined with acrivastine
the serum concentration of ibandronate can be diminished when it is combined with aluminium phosphate
the serum concentration of ibandronate can be diminished when it is combined with aluminum hydroxide
the risk or intensity of QTc prolongation can be heightened when ibandronate is combined with amantadine
the risk or intensity of QTc prolongation can be heightened when ibandronate is combined with amifampridine
Actions and Spectrum:
Actions:
Ibandronic acid stops bone breakdown, boosts bone density, and lowers fracture risk without affecting bone creation.
Spectrum:
Ibandronic acid treats high calcium levels in cancer and osteoporosis in postmenopausal women, maintaining normal levels for up to 36 days in severe cancer cases. In postmenopausal women, it lowers fracture risk and bone turnover.
Frequency not defined
Decreased appetite
Myalgia
Dizziness
Gastritis
Headache
Arthralgia
Flatulence
Muscle cramps
Nausea
Black Box Warning:
Avoid IBANDRONIC ACID if allergic to its components, have esophageal issues, cannot stand or sit upright for 60 minutes, or have low blood calcium. Inform your doctor about digestive issues, swallowing problems, kidney/liver problems, malabsorption syndrome, and dental plans. Potential side effects include low blood calcium, esophageal problems, severe jaw issues (osteonecrosis), bone/muscle pain, and uncommon thigh bone fractures. Keep your doctor informed about health and medications to prevent potential interactions or side effects.
Contraindication/Caution:
Contraindications
Hypersensitivity
Pediatrics
Galactosemia
Lactose intolerance
Glucose-galactose malabsorption
Pregnancy & breastfeeding
Hypocalcemia
Cautions
Renal impairment
Hepatic impairment
Drug interactions (NSAIDS, chemotherapy, corticosteroids)
Hypocalcemia
Prolonged oesophageal transit time
Dysphagia
Osteonecrosis
Pregnancy consideration:
Pregnancy category: C
Breastfeeding warnings:
No data is available regarding the excretion of drug in breast milk.
Pregnancy category:
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.
<b>Category B: There was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology:
Ibandronic acid is useful for cancer patients with bone metastases and women with osteoporosis, preventing fractures.
Pharmacodynamics:
Ibandronic acid stops bone breakdown, boosts bone density, and lowers fracture risk without affecting bone creation.
Pharmacokinetics:
Absorption
The bioavailability is >0.63%
Peak effect is reached in less than 1 hour.
Distribution
60% of protein bound.
Volume of distribution: 360 L.
Elimination and Excretion
Half-life ranges from 10 to 60 hours.
The drug is excreted through the kidneys, with a total body clearance of 130 mL/min and renal clearance of 88 mL/min.
Administration:
The route of administration is oral
Patient information leaflet
Generic Name: ibandronic acid
Pronounced: eye-BAN-droh-nik AS-id
Why do we use ibandronic acid?
The main indication for ibandronic acid use in postmenopausal women is osteoporosis.
Bone metastases from cancer patients can benefit from ibandronic acid.