ioflupane i-123

Action and Spectrum

Actions and Spectrum: 

Ioflupane is used in nuclear medicine imaging to assess brain dopamine transporter (DAT) density. It binds to DAT in presynaptic neurons reversibly and specifically. Upon injection it is distributed to the brain and detected using a gamma camera. The spectrum of ioflupane ranging from 159 keV to 172 keV determines the detector type and can affect the quality of the images produced by the gamma camera. 

Drug Interaction

Adverse Reaction

Frequency defined 

<1% 

Nausea 

Xerostomia 

Vertigo 

Headache 

Dizziness 

Black Box Warning

Contraindication / Caution

Contraindication/Caution: 

Ioflupane can cause allergic reactions, radiation exposure, and interference with other medications. It is not recommended for use in patients with known hypersensitivity, pregnant/breastfeeding women, children, Parkinson, severe renal impairment, or severe hepatic impairment.

Pregnancy / Lactation

Pregnancy consideration:  

US FDA pregnancy category: C 

Lactation:   

Excreted into human milk is Not known.  

Pregnancy category: 

• Category A: well-controlled and Satisfactory studies do not show risk to the fetus in the first/later trimester.        
• Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women        
• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.       
• Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.        
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.        
• Category N: There is no data available for the drug under this category 

Pharmacology

Pharmacology: 

Ioflupane is a radiopharmaceutical agent used for diagnostic imaging of the brain dopamine transporter (DAT).  

Pharmacodynamics: 

This drug targets the human recombinant dopamine transporter emitting gamma radiation that can be detected using gamma detectors allowing visualization of the brain striatal through SPECT imaging. 

Pharmacokinetics: 

Absorption 

It is not absorbed from the GIT. 

Distribution 

It is rapidly distributed throughout the body. 

Metabolism 

The metabolism involves decay to 123Te through electron capture. 

Elimination and Excretion 

It is excreted through urine and 60% of the total excretion within 48 hours. 14% excreted through feces. 

Adminstartion

Administration: 

Ioflupane IV used for diagnostic imaging with the dose and volume varying based on the procedure and patient weight. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: ioflupane 

Pronounced: [ EYE-oh-FLOO-payne] 

Why do we use ioflupane? 

Ioflupane used for diagnosing brain dopamine transporter loss in Parkinsonian syndromes. It helps in differential diagnosis, monitoring disease progression, evaluating movement disorders, and aiding in research to understand the pathophysiology of Parkinson disease and other movement disorders. It also aids in assessing changes in dopamine transporter density over time.